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- Title
Within-Host and Population Transmission of bla<sub>OXA-48</sub> in K. pneumoniae and E. coli.
- Authors
Haverkate, Manon R.; Dautzenberg, Mirjam J. D.; Ossewaarde, Tjaco J. M.; van der Zee, Anneke; den Hollander, Jan G.; Troelstra, Annet; Bonten, Marc J. M.; Bootsma, Martin C. J.
- Abstract
During a large hospital outbreak of OXA-48 producing bacteria, most K. pneumoniaeOXA-48 isolates were phenotypically resistant to meropenem or imipenem, whereas most E. coliOXA-48 isolates were phenotypically susceptible to these antibiotics. In the absence of molecular gene-detection E. coliOXA-48 could remain undetected, facilitating cross-transmission and horizontal gene transfer of blaOXA-48. Based on 868 longitudinal molecular microbiological screening results from patients carrying K. pneumoniaeOXA-48 (n = 24), E. coliOXA-48 (n = 17), or both (n = 40) and mathematical modelling we determined mean durations of colonisation (278 and 225 days for K. pneumoniaeOXA-48 and E. coliOXA-48, respectively), and horizontal gene transfer rates (0.0091/day from K. pneumoniae to E. coli and 0.0015/day vice versa). Based on these findings the maximum effect of horizontal gene transfer of blaOXA-48 originating from E. coliOXA-48 on the basic reproduction number (R0) is 1.9%, and it is, therefore, unlikely that phenotypically susceptible E. coliOXA-48 will contribute significantly to the spread of blaOXA-48.
- Subjects
PNEUMONIA; ESCHERICHIA coli diseases; EPIDEMICS; HOSPITAL patients; IMIPENEM; DISEASE susceptibility; INFECTIOUS disease transmission; THERAPEUTICS
- Publication
PLoS ONE, 2015, Vol 10, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0140960