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- Title
Sex differences in muscle contraction-induced limb blood flow limitations.
- Authors
Hammer, Shane M.; Sears, Kylie N.; Montgomery Jr, Tony R.; Olmos, Alex A.; Hill, Ethan C.; Trevino, Michael A.; Dinyer-McNeely, Taylor K.
- Abstract
Purpose: To determined sex differences in absolute- and %-reductions in blood flow during intermittent muscular contractions as well as relationships between blood flow reductions and time to task failure (TTF). Methods: Thirteen males (25 ± 4 years) and 13 females (22 ± 5 years) completed intermittent isometric trapezoidal forearm flexion at 50% maximal voluntary contraction until task failure. Doppler ultrasound was used to measure brachial artery blood flow (BABF) during the 12-s plateau phase and 12-s relaxation phase. Results: Target torque was less in females than males (24 ± 5 vs. 42 ± 7 Nm; p < 0.001); however, TTF was not different between sexes (F: 425 ± 187 vs. M: 401 ± 158 s; p = 0.72). Relaxation-phase BABF at end-exercise was less in females than males (435 ± 161 vs. 937 ± 281 mL/min; p < 0.001) but contraction-phase BABF was not different (127 ± 46 vs. 190 ± 99 mL/min; p = 0.42). Absolute- and %-reductions in BABF by contraction were less in females than males (309 ± 146 vs. 747 ± 210 mL/min and 69 ± 10 vs. 80% ± 6%, respectively; both p < 0.01) and were associated with target torque independent of sex (r = 0.78 and 0.56, respectively; both p < 0.01). Absolute BABF reduction per target torque (mL/min/Nm) and TTF were positively associated in males (r = 0.60; p = 0.031) but negatively associated in females (r = − 0.61; p = 0.029). Conclusions: This study provides evidence that females incur less proportional reduction in limb blood flow from muscular contraction than males at a matched relative intensity suggesting females may maintain higher levels of muscle oxygen delivery and metabolite removal than males across the contraction–relaxation cycle of intermittent exercise.
- Subjects
BLOOD flow; FOREARM; BRACHIAL artery; DOPPLER ultrasonography
- Publication
European Journal of Applied Physiology, 2024, Vol 124, Issue 4, p1121
- ISSN
1439-6319
- Publication type
Article
- DOI
10.1007/s00421-023-05339-5