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- Title
Host factor Ebp1 inhibits rinderpest virus transcription in vivo.
- Authors
Gopinath, M.; Raju, S.; Honda, A.; Shaila, M. S.
- Abstract
ErbB3 binding protein Ebp1 has been shown to downregulate ErbB3 receptor-mediated signaling to inhibit cell proliferation. Rinderpest virus belongs to the family Paramyxoviridae and is characterized by the presence of a non-segmented negative-sense RNA genome. In this work, we show that rinderpest virus infection of Vero cells leads to the down-regulation of the host factor Ebp1, at both the mRNA and protein levels. Ebp1 protein has been shown to co-localize with viral inclusion bodies in infected cells, and it is packaged into virions, presumably through its interaction with the N protein or the N-RNA itself. Overexpression of Ebp1 inhibits viral transcription and multiplication in infected cells, suggesting that a mutual antagonism operates between host factor Ebp1 and the virus.
- Subjects
CARRIER proteins; RINDERPEST virus; PARAMYXOVIRUSES; RNA; CELL proliferation
- Publication
Archives of Virology, 2010, Vol 155, Issue 4, p455
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-010-0599-y