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- Title
Treatment of bacterial vaginosis in women with vaginal bleeding complications or discharge and harboring Mobiluncus.
- Authors
Larsson, P.G.; Bergman, B.; Forsum, U.; Påhlson, C.; Påhlson, C
- Abstract
A double-blind study of treatment for bacterial vaginosis (BV), using metronidazole tablets 500 mg 3 times daily for 10 days versus placebo in the same regimen, was performed on 42 outpatients with irregular bleeding episodes or discharge attending a gynecological clinic. All patients had motile rods in wet smears in addition to fulfilling the criteria for BV. Treatment gave a cure rate of 76% versus 5% in the placebo group. Mobiluncus sp. was identified in 81% of these cases before treatment, in 8% of the cured patients and in 50% of those not initially cured at follow-up. Repeated treatments, once or twice, resulted in a 100% cure rate. A 6-month follow-up was carried out on 39 of the 42 patients. There were 7 relapses after 6 months giving a cure rate of 82%. After successful treatment all bleeding disturbances disappeared. We conclude that it is important to treat BV in patients with symptoms other than malodorous discharge.
- Subjects
BACTERIAL disease complications; METRONIDAZOLE; ANAEROBIC bacteria; BACTERIAL diseases; COMPARATIVE studies; DRUG administration; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STATISTICAL sampling; UTERINE hemorrhage; VAGINITIS; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment; LEUKORRHEA; DISEASE complications; THERAPEUTICS
- Publication
Gynecologic & Obstetric Investigation, 1990, Vol 29, Issue 4, p296
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000293339