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- Title
Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2- A]Benzimidazoles.
- Authors
Zhukovskaya, O.; Spasov, A.; Kuz'menko, T.; Morkovnik, A.; Kucheryavenko, A.; Anisimova, V.; Salaznikova, O.; Gaidukova, K.; Kuznetsova, V.; Babkov, D.; Grechko, O.; Eliseeva, N.; Rashchenko, A.
- Abstract
A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2- a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone or 1-bromo-3,3,3-trifluoroacetone and were tested for analgesic and antiplatelet activity, glycogen phosphorylase and dipeptidyl peptidase-4 inhibitory activity, and in vitro glycation of bovine serum albumin.
- Subjects
BIOSYNTHESIS; TRIFLUOROMETHYL compounds synthesis; BENZIMIDAZOLES; ACETONE; CD26 antigen; GLYCOGEN phosphorylase
- Publication
Pharmaceutical Chemistry Journal, 2018, Vol 52, Issue 5, p385
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-018-1826-1