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- Title
Identificación de la proteína "Spike" en sangre de cordón umbilical de recién nacidos de madres vacunadas contra SARS-CoV-2 durante el embarazo.
- Authors
Malfavón Farías, Montserrat; Vázquez Camacho, Eric Emilio; Jesús Borboa-Olivares, Héctor; Flores Manzur, María de los Ángeles; Santiago Sanabria, Leopoldo
- Abstract
OBJECTIVE: Identification of the presence of SARS-CoV-2 Spike protein antibodies in cord blood of newborns following maternal COVID-19 vaccination during pregnancy. MATERIALS AND METHODS: Cross-sectional study in vaccinated women during pregnancy who had a cord blood sample taken during the surgical procedure (Vaginal birth/Cesarean section) to measure spike protein antibodies. RESULTS: We registered 219 patients in the study: five types of vaccines, from two different platforms, were tested: Pfizer®, Moderna®, AstraZeneca®, J&J/Janssen® and Sputnik®. The levels of antibodies were greater in those patients vaccinated with Moderna ® and Sputnik®. Through a Cox regression we made a predictive model where we observed that there are no differences in the number of antibodies generated after the first and second vaccine dose. CONCLUSIONS: Prenatal vaccination against COVID-19 induces a strong maternal humoral response that is effectively transferred to the fetus, even with a single dose.
- Subjects
CORONAVIRUS spike protein; SARS-CoV-2; PREGNANT women; COVID-19 vaccines; CORD blood; NEWBORN infants
- Publication
Ginecología y Obstetricia de México, 2024, Vol 92, Issue 5, p189
- ISSN
0300-9041
- Publication type
Article
- DOI
10.24245/gom.v92i5.9201