We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
genBlastG: using BLAST searches to build homologous gene models.
- Authors
She, Rong; Chu, Jeffrey Shih-Chieh; Uyar, Bora; Wang, Jun; Wang, Ke; Chen, Nansheng
- Abstract
Motivation: BLAST users frequently expect to obtain homologous genes with certain similarity to their query genes. But what they get from BLAST searches are often collections of local alignments called high-scoring segment pairs (HSPs). On the other hand, most homology-based gene finders have been built using computation-intensive algorithms, without taking full advantage of BLAST searches that have been perfected over the last decades.Results: Here we report an efficient algorithm, genBlastG that directly uses the HSPs reported by BLAST to define high-quality gene models.Availability: http://genome.sfu.ca/genblast/download.htmlContact: chenn@sfu.caSupplementary information: Supplementary data are available at Bioinformatics online.
- Subjects
GENES; HOMOLOGOUS chromosomes; GENOMES; HOMOLOGY (Biochemistry); GENETIC algorithms
- Publication
Bioinformatics, 2011, Vol 27, Issue 15, p2141
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btr342