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- Title
NF-κB at the crossroads of life and death.
- Authors
Karin, Michael; Lin, Anning
- Abstract
The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial antigens are selected to survive and proliferate in response to infection, whereas those that are self-reactive are eliminated via apoptosis. Even the survival of alloreactive T cells requires their proper costimulation and, when infection subsides, the activated T cells are eliminated. A major regulator of such life or death decisions is the transcription factor NF-κB. However, NF-κB cannot function alone. A variety of mechanisms exist to modulate its activity and thereby affect the ultimate outcome of a cell's fate.
- Subjects
TRANSCRIPTION factors; CYTOKINES; DNA-binding proteins
- Publication
Nature Immunology, 2002, Vol 3, Issue 3, p221
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni0302-221