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- Title
QuEChERS-HPLC-MS/MS法测定4种化妆品基质中 15种硝基咪哇类非法添加药物的基质效应研究
- Authors
陈岑; 颜琳琦; 程巧鸳
- Abstract
A QnEChERS coupled with high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method was developed for the detection of 15 nitroimidazole drugs illegally added in 4 kinds of cosmetic matrices. The matrix effects of 15 nitroimidazole drugs in water aqua, powder, lotion and cream, together with the influences of matrix type, matrix mass concentration and drug mass concentration on the matrix effects were discussed. The result show that the 4 kinds of cosmetic have different degrees of matrix effects on 15 nitroimidazole drugs, and most of them are matrix inhibitory effects, which are impacted by matrix type, matrix mass concentration and drug mass concentration. Therefore, it's crucial to take matrix effect into consideration during the detection of the nitroimidazoles illegally added in cosmetic products. For some matrices with weak matrix effects, such as water aqua and powder, the matrix effects can be ignored according to actual needs. For emulsions and cream substrates with significant matrix effects, it is recommended to use a matrixmatched standard curve for quantitative analysis to ensure the accuracy of the test results.
- Subjects
HIGH performance liquid chromatography; MATRIX effect; TANDEM mass spectrometry; NITROIMIDAZOLES; QUANTITATIVE research
- Publication
China Surfactant Detergent & Cosmetics, 2020, Vol 50, Issue 4, p275
- ISSN
1001-1803
- Publication type
Article
- DOI
10.3969/j.issn.1001-1803.2020.04.011