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- Title
Investigation of the Antidiabetic Effects of Mistletoe (Viscum album L.) Extract in Experimental Diabetes in Rats.
- Authors
AHMED, Avin Kawa; MERT, Handan; MERT, Nihat
- Abstract
Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies distinguished by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. Extracts of the V. album leaves was reported to exert a beneficial effect to alleviate the symptoms of diabetes in local medicines. The aim of present investigation is to evaluate the antidiabetic and antioxidant activities of V. album extracts on streptozotocin (STZ) induced diabetic rats. Thirty two female Wistar albino rats, aging 6-7 weeks, were included in the present study. The rats were randomly divided into 4 groups: Group I (Control), Group II (V. album), Group III (Diabeteic), Group IV (Diabetic + V. album). After experimental period, all animals were decapitated, blood was collected and sera were separated. Serum concentrations of total cholesterol, high density lipoprotein, cholesterol, triglyceride, folic acid, vitamin D, vitamin B12 and glucose were determined by using automatic analyzer. Total Antioxidant Capacity (TAC) and Total Oxidative Status (TOS) analyses were measured ELISA. The levels of glucose (p≤0.05), vitamin B12 (p≤0.05), TOS (p≤0.05) were significantly decreased and TAC (p≤0.05) increased in diabetic+V. album group compared to diabetic group. In conclusion extracts of V. album have antidiabetic effects that significantly decreased glucose level when treated with V. album only 20 days of experiment. Viscum album had a stronge antioxidant activity that can help to prevent the formation of diabetic complications.
- Subjects
STREPTOZOTOCIN; OXIDANT status; VITAMIN B12; VITAMIN D; MISTLETOES; PROTEIN metabolism
- Publication
Van Veterinary Journal, 2019, Vol 30, Issue 2, p121
- ISSN
2149-3359
- Publication type
Article