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- Title
MicroRNA Regulation of RAD51 in Serous Ovarian Cancer and Chemotherapy Response.
- Authors
Wiemer, Erik A. C.; Berns, Els M. J. J.
- Abstract
The authors comment on the effect of the expression of microRNA-506 on chemotherapy response in serous ovarian cancer. They discuss a study which found that the expression of microRNA-506 in serous ovarian tumor cells is capable of augmenting the response to cisplatin and the PARP inhibitor olaparib. They also compare the results to a study which identified a cluster of miRNA at chrXq27.3 that was statistically significantly downregulated in patients who have an early relapse.
- Subjects
MICRORNA; OVARIAN cancer treatment; CANCER chemotherapy; CISPLATIN; CANCER cells; DOWNREGULATION
- Publication
JNCI: Journal of the National Cancer Institute, 2015, Vol 107, Issue 7, p1
- ISSN
0027-8874
- Publication type
Editorial
- DOI
10.1093/jnci/djv161