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- Title
Cell-Based Therapy for Urethral Regeneration: A Narrative Review and Future Perspectives.
- Authors
Jin, Yangwang; Zhao, Weixin; Yang, Ming; Fang, Wenzhuo; Gao, Guo; Wang, Ying; Fu, Qiang
- Abstract
Urethral stricture is a common urological disease that seriously affects quality of life. Urethroplasty with grafts is the primary treatment, but the autografts used in clinical practice have unavoidable disadvantages, which have contributed to the development of urethral tissue engineering. Using various types of seed cells in combination with biomaterials to construct a tissue-engineered urethra provides a new treatment method to repair long-segment urethral strictures. To date, various cell types have been explored and applied in the field of urethral regeneration. However, no optimal strategy for the source, selection, and application conditions of the cells is available. This review systematically summarizes the use of various cell types in urethral regeneration and their characteristics in recent years and discusses possible future directions of cell-based therapies.
- Subjects
REGENERATION (Biology); TISSUE engineering; URINARY organ diseases; URETHROPLASTY; URETHRA diseases; AUTOGRAFTS; URETHRA stricture
- Publication
Biomedicines, 2023, Vol 11, Issue 9, p2366
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11092366