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- Title
Statin Use Ameliorates Survival in Oral Squamous Cell Carcinoma—Data from a Population-Based Cohort Study Applying Propensity Score Matching.
- Authors
Spoerl, Steffen; Gerken, Michael; Fischer, René; Spoerl, Silvia; Kirschneck, Christian; Wolf, Stefanie; Taxis, Juergen; Ludwig, Nils; Biermann, Niklas; Reichert, Torsten E.; Spanier, Gerrit
- Abstract
The anti-cancer properties of statins have attracted much attention recently, but little is known about the prognostic role of statins in oral squamous cell carcinoma (OSCC). In a retrospective approach, we analyzed a population-based cohort of 602 OSCC patients with primary curative tumor resection to negative margins and concomitant neck dissection between 2005–2017. Long-term medication with statins was correlated with overall survival (OAS) as well as recurrence-free survival (RFS) using uni- and multivariable Cox regression. Additionally, propensity score matching was applied to adjust for confounders. Statin use was present in 96 patients (15.9%) at a median age of 65.7 years. Statin treatment correlated with ameliorated survival in multivariable Cox regression in the complete cohort (OAS: HR 0.664; 95% CI 0.467–0.945, p = 0.023; RFS: HR 0.662; 95% CI 0.476–0.920, p = 0.014) as well as matched-pair cohort of OSCC patients (OAS: HR 0.691; 95% CI 0.479–0.997, p = 0.048; RFS: HR 0.694; 95% CI 0.493–0.976, p = 0.036) when compared to patients not taking statins at time of diagnosis. These findings were even more pronounced by sub-group analysis in the matched-pair cohort (age < 70 years). These data indicate that statin use might ameliorate the oncological outcome in primarily resected OSCC patients, but prospective clinical trials are highly recommended.
- Subjects
ORGANIZATION of American States; PROPENSITY score matching; SQUAMOUS cell carcinoma; STATINS (Cardiovascular agents); COHORT analysis; SURGICAL margin
- Publication
Biomedicines, 2023, Vol 11, Issue 2, p369
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines11020369