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- Title
Evaluation of Short-Term Efficacy of Concurrent Chemoradiotherapy in Primary Fallopian Tube Carcinoma by Diffusion-Weighted Imaging: A Retrospective Study.
- Authors
Ye-Wei Liu; Ya-Fei Du; Hong-Zhen Zhang; Gui-Ying Fang; Yu-Xiang Zhang; Jing Ge; Jing Liu
- Abstract
Background: This study aims to evaluate the short-term efficacy of concurrent chemoradiotherapy (CCRT) in primary fallopian tube carcinoma (PFTC) using magnetic resonance diffusion-weighted imaging (MR-DWI). Patients and Methods: Total abdominal irradiation was performed for 61 PFTC patients after surgery, and paclitaxel and carboplatin were used for CCRT. According to the response evaluation criteria in solid tumors (RECIST1.1), patients were divided into a sensitive (n = 36) and a resistant group (n = 25). Pearson correlation analysis was conducted to assess the correlations of tumor regression rate with apparent diffusion coefficient (ADC)pre, ADCpost, and ΔADCpost. The efficacy of CCRT in PFTC using MR-DWI was evaluated by ROC curve, logistic regression analysis, Kaplan-Meier survival curve, and Cox regression model. Results: The ADCpre in both the sensitive and the resistant group was negatively associated with the tumor regression rate (r = -0.508), while the ADCpost (r = 0.454) and ΔADCpost (r = 0.769) were positively associated with the tumor regression rate (all p < 0.05). Histopathological type, FIGO stage, lymphatic metastasis, tumor regression rate, ADCpre, ADCpost, and ΔADCpost were confirmed as key factors for CCRT in PFTC (all p < 0.05). Conclusion: Our retrospective study demonstrates the predictive value of MR-DWI in CCRT for PFTC patients.
- Subjects
CHEMORADIOTHERAPY; FALLOPIAN tubes; FALLOPIAN tube diseases; ULTRASONIC imaging of fallopian tubes; PEARSON correlation (Statistics); LOGISTIC regression analysis; DIAGNOSIS; CANCER
- Publication
Oncology Research & Treatment, 2017, Vol 40, Issue 5, p281
- ISSN
2296-5270
- Publication type
Article
- DOI
10.1159/000464354