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- Title
TOGging up microtubule ends: The plant-specific microtubule minus-end tracking SPR2 has a unique TOG domain.
- Authors
Kolli, Renuka
- Abstract
This article, published in the Plant Cell journal, discusses the role of the plant-specific microtubule minus-end tracking SPR2 protein in regulating microtubule dynamics. Unlike animals, plants lack certain proteins that regulate microtubule minus-end dynamics, but instead have SPR2. The article presents the X-ray crystallography-based structure of the SPR2 N-terminal domain, revealing a unique Tumor Overexpressed Gene (TOG) domain. The study shows that the TOG domain, along with the basic region and coiled-coil domain, is important for stabilizing microtubule minus-ends. The findings suggest that plants have co-opted the TOG domain to regulate microtubule dynamics.
- Subjects
MICROTUBULES; TUBULINS
- Publication
Plant Cell, 2024, Vol 36, Issue 4, p803
- ISSN
1040-4651
- Publication type
Article
- DOI
10.1093/plcell/koad323