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- Title
Synthesis of 4,5-Dihydroisoxazoles from Arylcyclopropanes and Nitrosyl Chloride.
- Authors
Bondarenko, O. B.; Gavrilova, A. Yu.; Saginova, L. G.; Zyk, N. V.
- Abstract
Arylcyclopropanes readily react with nitrosyl chloride in liquid sulfur dioxide to give the corresponding 5-aryl-4,5-dihydroisoxazoles in good yield. The reaction is most selective at -40 to -50°C; at higher temperature, the contribution of side processes becomes appreciable. The complete conversion of arylcyclopropanes containing donor substituents is attained with the use of 1.5 equiv of nitrosyl chloride, while the rate of the transformation of compounds with nonactivated aromatic rings considerably increases on raising the molar ratio NOCl-arylcyclopropane.
- Subjects
RING formation (Chemistry); NITROSYL chloride; SULFUR; NITROGEN oxychlorides; PROPANE; CHLORINE compounds
- Publication
Russian Journal of Organic Chemistry, 2003, Vol 39, Issue 7, p1021
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1023/B:RUJO.0000003196.89457.a4