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- Title
Critical Role of Inflammation and Specialized Pro-Resolving Mediators in the Pathogenesis of Atherosclerosis.
- Authors
Rangarajan, Subhapradha; Orujyan, Davit; Rangchaikul, Patrida; Radwan, Mohamed M.
- Abstract
Recent research on how the body resolves this inflammation is gaining traction and has shed light on new avenues for future management of cardiovascular diseases. In this narrative review, we discuss the pathophysiological mechanisms of atherosclerosis, the recent development in the understanding of a new class of molecules called Specialized Pro-resolving Mediators (SPMs), and the impact of such findings in the realm of cardiovascular treatment options. We searched the MEDLINE database restricting ourselves to original research articles as much as possible on the complex pathophysiology of atherosclerosis and the role of SPMs. We expect to see further research in translating these findings to bedside clinical trials in treating conditions with a pathophysiological basis of inflammation, such as coronary artery disease, asthma, and periodontal disease.
- Subjects
INFLAMMATION; CORONARY artery disease; ATHEROSCLEROSIS; PATHOGENESIS; CARDIOVASCULAR diseases; PERIODONTITIS
- Publication
Biomedicines, 2022, Vol 10, Issue 11, p2829
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10112829