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- Title
The Role of Microglia in the Development of Neurodegenerative Diseases.
- Authors
Lee, Jae-Won; Chun, Wanjoo; Lee, Hee Jae; Kim, Seong-Man; Min, Jae-Hong; Kim, Doo-Young; Kim, Mun-Ock; Ryu, Hyung Won; Lee, Su Ui
- Abstract
Microglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial activation. In this review, we summarize the contribution of microglial activation and its associated mechanisms in NDs, such as epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), based on recent observations. This review also briefly introduces experimental animal models of epilepsy, AD, PD, and HD. Thus, this review provides a better understanding of microglial functions in the development of NDs, suggesting that microglial targeting could be an effective therapeutic strategy for these diseases.
- Subjects
NEURODEGENERATION; HUNTINGTON disease; MICROGLIA; PARKINSON'S disease; ALZHEIMER'S disease
- Publication
Biomedicines, 2021, Vol 9, Issue 10, p1449
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines9101449