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- Title
Renal Protective Effect of DPP-4 Inhibitors in Type 2 Diabetes Mellitus Patients: A Cohort Study.
- Authors
Kim, Young-Gun; Byun, JungHyun; Yoon, Dukyong; Jeon, Ja Young; Han, Seung Jin; Kim, Dae Jung; Lee, Kwan-Woo; Park, Rae Woong; Kim, Hae Jin
- Abstract
Aims. Dipeptidyl-peptidase IV inhibitors (DPP-4i) are among the most popular oral antidiabetic agents. However, the effects of DPP-4i on diabetic nephropathy are not well-established. The aim of this study was to determine the renoprotective effects of DPP-4i, using albuminuria and glomerular filtration rate (GFR) as indicators, in type 2 diabetes mellitus (T2DM) patients. Methods. This retrospective observational cohort study used the clinical database of a tertiary hospital. The changes of urine albumin/creatinine ratio (UACR), estimated GFR (eGFR), and metabolic parameters after treatment were compared with the changes of those parameters before treatment using paired Student’s t-test. Results. The mean UACR in the entire study population decreased to approximately 45 mg/g 1 year after DPP-4i treatment, while it was increased approximately 39 mg/g 1 year before DPP-4i treatment (p<0.05). Patients with macroalbuminuria showed a significant reduction in albumin levels after DPP-4i treatment (p<0.05); however, patients with microalbuminuria and normoalbuminuria did not show improvements in albuminuria levels after treatment. Although eGFR was not changed 1 year after DPP-4i treatment, reductions in eGFR were slowed in patients with microalbuminuria and reversed in the macroalbuminuria or normoalbuminuria groups, 4 years after treatment. Conclusions. Administration of DPP-4i reduces urine albumin excretion and mitigates reduction of eGFR in T2DM patients.
- Subjects
PEOPLE with diabetes; TYPE 2 diabetes treatment; CD26 antigen; DRUG efficacy; DRUG administration
- Publication
Journal of Diabetes Research, 2016, p1
- ISSN
2314-6745
- Publication type
Article
- DOI
10.1155/2016/1423191