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- Title
Caution: merging ion channel traffic ahead.
- Authors
Burgess, Don E.; Delisle, Brian P.
- Abstract
Keywords: action potential; arrhythmias; heart; ion channels; modelling; potassium current EN action potential arrhythmias heart ion channels modelling potassium current 2541 2542 2 07/04/23 20230701 NES 230701 I KCNH2 i , also known as the I human ether-à-go-go related-gene i or I hERG i , encodes the Kv11.1 channel proteins that conduct the rapidly activating delayed rectifier K SP + sp current ( I I i SB Kr sb ) in the heart. For example, HT <math display="inline" altimg="urn:x-wiley:00223751:media:tjp15501:tjp15501-math-0008" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi>p</mi><mo>=</mo><mrow><mi> </mi><mi mathvariant="normal"> </mi></mrow><mi>t</mi></mrow><annotation encoding="application/x-tex">$p = {\rm{\psi \Delta }}t$</annotation></semantics></math> ht gives the probability that an ion channel comes into existence during a time interval ( HT <math display="inline" altimg="urn:x-wiley:00223751:media:tjp15501:tjp15501-math-0009" xmlns="http://www.w3.org/1998/Math/MathML"><semantics><mrow><mi mathvariant="normal"> </mi><mi>t</mi></mrow><annotation encoding="application/x-tex">${{\Delta}}t$</annotation></semantics></math> ht ).
- Subjects
ION channels; POTASSIUM channels; ACTION potentials; COMPUTATIONAL biology; ARRHYTHMIA
- Publication
Journal of Physiology, 2023, Vol 601, Issue 13, p2541
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP284497