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- Title
Cross Talk rebuttal: Kirby and Dupont‐Versteegden.
- Authors
Kirby, Tyler J.; Dupont‐Versteegden, Esther E.
- Abstract
Keywords: ageing; muscle atrophy; myonuclear apoptosis EN ageing muscle atrophy myonuclear apoptosis 2085 2086 2 05/02/22 20220501 NES 220501 In their Cross Talk article, Drs Schwartz and Gundersen (2022) argue that myonuclear apoptosis cannot occur, because it would not be possible to compartmentalize and restrict this event to individual myonuclei within the myofibre syncytium. Cross Talk opposing view: Myonuclei do not undergo apoptosis during skeletal muscle atrophy. We agree with the opposing authors that some early studies did not adequately identify apoptosis specifically in myonuclei during disuse atrophy; however, numerous recent studies have demonstrated myonuclear loss in isolated myofibres with appropriate myofibre delineation (Snijders et al., 2020).
- Subjects
MUSCULAR atrophy; MYONEURAL junction; MUSCULAR dystrophy; MUSCLE cells; MUSCLE aging
- Publication
Journal of Physiology, 2022, Vol 600, Issue 9, p2085
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP283000