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PINK1 autophosphorylation is required for ubiquitin recognition.
Published in:
EMBO Reports, 2018, v. 19, n. 4, p. 1, doi. 10.15252/embr.201744981
By:
- Rasool, Shafqat;
- Soya, Naoto;
- Truong, Luc;
- Croteau, Nathalie;
- Lukacs, Gergely L.;
- Trempe, Jean‐François
Publication type:
Article
A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants.
Published in:
Journal of Personalized Medicine, 2021, v. 11, n. 7, p. 643, doi. 10.3390/jpm11070643
By:
- Veit, Guido;
- Velkov, Tony;
- Xu, Haijin;
- Vadeboncoeur, Nathalie;
- Bilodeau, Lara;
- Matouk, Elias;
- Lukacs, Gergely L.
Publication type:
Article
Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells.
Published in:
Journal of Cell Biology, 2004, v. 167, n. 5, p. 851, doi. 10.1083/jcb.200404105
By:
- Lechardeur, Deiphine;
- Ming Xu;
- Lukacs, Gergely L.
Publication type:
Article
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.
Published in:
Journal of Cell Biology, 2004, v. 164, n. 6, p. 923, doi. 10.1083/jcb.200312018
By:
- Sharma, Manu;
- Pampinella, Francesca;
- Nemes, Csilla;
- Benharouga, Mohamed;
- So, Jeffrey;
- Kai Du;
- Bache, Kristi G.;
- Papsin, Blake;
- Zerangue, Noa;
- Stenmark, Harald;
- Lukacs, Gergely L.
Publication type:
Article
COOH-terminal Truncations Promote Proteasome-dependent Degradation of Mature Cystic Fibrosis...
Published in:
Journal of Cell Biology, 2001, v. 153, n. 5, p. 957, doi. 10.1083/jcb.153.5.957
By:
- Benharouga, Mohamed;
- Haardt, Martin;
- Kartner, Norbert;
- Lukacs, Gergely L.
Publication type:
Article
Importin 13 Regulates Nuclear Import of the Glucocorticoid Receptor in Airway Epithelial Cells.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2006, v. 35, n. 6, p. 668, doi. 10.1165/rcmb.2006-0073oc
By:
- Tao Tao;
- Jie Lan;
- Lukacs, Gergely L.;
- Haché, Robert J. G.;
- Kaplan, Feige
Publication type:
Article
Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines.
Published in:
Cells (2073-4409), 2021, v. 10, n. 3, p. 495, doi. 10.3390/cells10030495
By:
- Grund, Megan E.;
- Choi Soo, Jeon;
- Cote, Christopher K.;
- Berisio, Rita;
- Lukomski, Slawomir;
- Lukacs, Gergely L.
Publication type:
Article
Discovery of novel potent ΔF508- CFTR correctors that target the nucleotide binding domain.
Published in:
EMBO Molecular Medicine, 2013, v. 5, n. 10, p. 1484, doi. 10.1002/emmm.201302699
By:
- Odolczyk, Norbert;
- Fritsch, Janine;
- Norez, Caroline;
- Servel, Nathalie;
- da Cunha, Melanie Faria;
- Bitam, Sara;
- Kupniewska, Anna;
- Wiszniewski, Ludovic;
- Colas, Julien;
- Tarnowski, Krzysztof;
- Tondelier, Danielle;
- Roldan, Ariel;
- Saussereau, Emilie L.;
- Melin‐Heschel, Patricia;
- Wieczorek, Grzegorz;
- Lukacs, Gergely L.;
- Dadlez, Michal;
- Faure, Grazyna;
- Herrmann, Harald;
- Ollero, Mario
Publication type:
Article
Quality control for unfolded proteins at the plasma membrane.
Published in:
Journal of Cell Biology, 2010, v. 191, n. 3, p. 553, doi. 10.1083/jcb.201006012
By:
- Apaja, Pirjo M.;
- Haijin Xu;
- Lukacs, Gergely L.
Publication type:
Article
N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic.
Published in:
Journal of Cell Biology, 2009, v. 184, n. 6, p. 847, doi. 10.1083/jcb.200808124
By:
- Glozman, Rina;
- Okiyoneda, Tsukasa;
- Mulvihill, Cory M.;
- Rini, James M.;
- Barriere, Herve;
- Lukacs, Gergely L.
Publication type:
Article
Site-specific ubiquitination exposes a linear motif to promote interferon-α receptor endocytosis.
Published in:
Journal of Cell Biology, 2007, v. 179, n. 5, p. 935, doi. 10.1083/jcb.200706034
By:
- Kumar, K. G. Suresh;
- Barriere, Hervé;
- Carbone, Christopher J.;
- Liu, Jianghuai;
- Swaminathan, Gayathri;
- Xu, Ping;
- Li, Ying;
- Baker, Darren P.;
- Peng, Junmin;
- Lukacs, Gergely L.;
- Fuchs, Serge Y.
Publication type:
Article
Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46639-1
By:
- Armirotti, Andrea;
- Tomati, Valeria;
- Matthes, Elizabeth;
- Veit, Guido;
- Cholon, Deborah M.;
- Phuan, Puay-Wah;
- Braccia, Clarissa;
- Guidone, Daniela;
- Gentzsch, Martina;
- Lukacs, Gergely L.;
- Verkman, Alan S.;
- Galietta, Luis J. V.;
- Hanrahan, John W.;
- Pedemonte, Nicoletta
Publication type:
Article
Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-42331-6
By:
- Foo, Brian;
- Barbier, Camille;
- Guo, Kevin;
- Vasantharuban, Jaminie;
- Lukacs, Gergely L.;
- Shrier, Alvin
Publication type:
Article
Identification of Allosteric Inhibitors against Active Caspase-6.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41930-7
By:
- Tubeleviciute-Aydin, Agne;
- Beautrait, Alexandre;
- Lynham, Jeffrey;
- Sharma, Gyanesh;
- Gorelik, Alexei;
- Deny, Ludovic J.;
- Soya, Naoto;
- Lukacs, Gergely L.;
- Nagar, Bhushan;
- Marinier, Anne;
- LeBlanc, Andrea C.
Publication type:
Article
Introduction / Introduction.
Published in:
Biochemistry & Cell Biology, 2010, v. 88, n. 2, p. v, doi. 10.1139/O09-911
By:
- Hue Sun Chan;
- Lukacs, Gergely L.
Publication type:
Article
Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.
Published in:
Cellular & Molecular Life Sciences, 2022, v. 79, n. 9, p. 1, doi. 10.1007/s00018-022-04528-3
By:
- Pranke, Iwona Maria;
- Chevalier, Benoit;
- Premchandar, Aiswarya;
- Baatallah, Nesrine;
- Tomaszewski, Kamil F.;
- Bitam, Sara;
- Tondelier, Danielle;
- Golec, Anita;
- Stolk, Jan;
- Lukacs, Gergely L.;
- Hiemstra, Pieter S.;
- Dadlez, Michal;
- Lomas, David A.;
- Irving, James A.;
- Delaunay-Moisan, Agnes;
- van Anken, Eelco;
- Hinzpeter, Alexandre;
- Sermet-Gaudelus, Isabelle;
- Edelman, Aleksander
Publication type:
Article
Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress.
Published in:
Cellular & Molecular Life Sciences, 2022, v. 79, n. 3, p. 1, doi. 10.1007/s00018-022-04191-8
By:
- Wang, Ben B.;
- Xu, Haijin;
- Isenmann, Sandra;
- Huang, Cheng;
- Elorza-Vidal, Xabier;
- Rychkov, Grigori Y.;
- Estévez, Raúl;
- Schittenhelm, Ralf B.;
- Lukacs, Gergely L.;
- Apaja, Pirjo M.
Publication type:
Article
Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
Published in:
Nature Chemical Biology, 2013, v. 9, n. 7, p. 444, doi. 10.1038/nchembio.1253
By:
- Okiyoneda, Tsukasa;
- Veit, Guido;
- Dekkers, Johanna F;
- Bagdany, Miklos;
- Soya, Naoto;
- Xu, Haijin;
- Roldan, Ariel;
- Verkman, Alan S;
- Kurth, Mark;
- Simon, Agnes;
- Hegedus, Tamas;
- Beekman, Jeffrey M;
- Lukacs, Gergely L
Publication type:
Article
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Published in:
Nature Chemical Biology, 2010, v. 6, n. 1, p. 25, doi. 10.1038/nchembio.275
By:
- Hutt, Darren M.;
- Herman, David;
- Rodrigues, Ana P. C.;
- Noel, Sabrina;
- Pilewski, Joseph M.;
- Matteson, Jeanne;
- Hoch, Ben;
- Kellner, Wendy;
- Kelly, Jeffery W.;
- Schmidt, Andre;
- Thomas, Philip J.;
- Matsumura, Yoshihiro;
- Skach, William R.;
- Gentzsch, Martina;
- Riordan, John R.;
- Sorscher, Eric J.;
- Okiyoneda, Tsukasa;
- Yates III, John R.;
- Lukacs, Gergely L.;
- Frizzell, Raymond A.
Publication type:
Article
Analysis of AlphaMissense data in different protein groups and structural context.
Published in:
Scientific Data, 2024, v. 11, n. 1, p. 1, doi. 10.1038/s41597-024-03327-8
By:
- Tordai, Hedvig;
- Torres, Odalys;
- Csepi, Máté;
- Padányi, Rita;
- Lukács, Gergely L.;
- Hegedűs, Tamás
Publication type:
Article
Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations.
Published in:
Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1389586
By:
- Premchandar, Aiswarya;
- Ming, Ruiji;
- Baiad, Abed;
- Da Fonte, Dillon F.;
- Haijin Xu;
- Faubert, Denis;
- Veit, Guido;
- Lukacs, Gergely L.
Publication type:
Article
Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl− channel function and trafficking.
Published in:
Journal of Physiology, 2017, v. 595, n. 22, p. 6993, doi. 10.1113/JP275087
By:
- Gaitán‐Peñas, Héctor;
- Apaja, Pirjo M;
- Arnedo, Tanit;
- Castellanos, Aida;
- Elorza‐Vidal, Xabier;
- Soto, David;
- Gasull, Xavier;
- Lukacs, Gergely L;
- Estévez, Raúl
Publication type:
Article
Molecular Basis of Oligoubiquitin-Dependent Internalization of Membrane Proteins in Mammalian Cells.
Published in:
Traffic, 2006, v. 7, n. 3, p. 282, doi. 10.1111/j.1600-0854.2006.00384.x
By:
- Barriere, Herve;
- Nemes, Csilla;
- Lechardeur, Delphine;
- Khan-Mohammad, Mina;
- Fruh, Klaus;
- Lukacs, Gergely L.
Publication type:
Article
Dominant and Recessive Distal Renal Tubular Acidosis Mutations of Kidney Anion Exchanger 1 Induce Distinct Trafficking Defects in MDCK Cells.
Published in:
Traffic, 2006, v. 7, n. 2, p. 117, doi. 10.1111/j.1600-0854.2005.00366.x
By:
- Cordat, Emmanuelle;
- Kittanakom, Saranya;
- Yenchitsomanus, Pa-thai;
- Jing Li;
- Kai Du;
- Lukacs, Gergely L.;
- Reithmeier, Reinhart A. F.
Publication type:
Article
Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.
Published in:
Human Molecular Genetics, 2013, v. 22, n. 21, p. 4405, doi. 10.1093/hmg/ddt290
By:
- Capdevila-Nortes, Xavier;
- López-Hernández, Tania;
- Apaja, Pirjo M.;
- López de Heredia, Miguel;
- Sirisi, Sònia;
- Callejo, Gerard;
- Arnedo, Tanit;
- Nunes, Virginia;
- Lukacs, Gergely L.;
- Gasull, Xavier;
- Estévez, Raúl
Publication type:
Article
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.
Published in:
Human Molecular Genetics, 2012, v. 21, n. 3, p. 623, doi. 10.1093/hmg/ddr496
By:
- Colas, Julien;
- Faure, Grazyna;
- Saussereau, Emilie;
- Trudel, Stéphanie;
- Rabeh, Wael M.;
- Bitam, Sara;
- Guerrera, Ida Chiara;
- Fritsch, Janine;
- Sermet-Gaudelus, Isabelle;
- Davezac, Noëlie;
- Brouillard, Franck;
- Lukacs, Gergely L.;
- Herrmann, Harald;
- Ollero, Mario;
- Edelman, Aleksander
Publication type:
Article
Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects.
Published in:
Human Molecular Genetics, 2008, v. 17, n. 23, p. 3728, doi. 10.1093/hmg/ddn269
By:
- Duarri, Anna;
- Teijido, Oscar;
- López-Hernández, Tania;
- Scheper, Gert C.;
- Barriere, Herve;
- Boor, Ilja;
- Aguado, Fernando;
- Zorzano, Antonio;
- Palacín, Manuel;
- Martínez, Albert;
- Lukacs, Gergely L.;
- van der Knaap, Marjo S.;
- Nunes, Virginia;
- Estévez, Raúl
Publication type:
Article
Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00444-4
By:
- Bagdany, Miklos;
- Veit, Guido;
- Fukuda, Ryosuke;
- Avramescu, Radu G.;
- Okiyoneda, Tsukasa;
- Baaklini, Imad;
- Singh, Jay;
- Sovak, Guy;
- Haijin Xu;
- Apaja, Pirjo M.;
- Sattin, Sara;
- Beitel, Lenore K.;
- Roldan, Ariel;
- Colombo, Giorgio;
- Balch, William;
- Young, Jason C.;
- Lukacs, Gergely L.
Publication type:
Article
Analysis of Differential Lipofection Efficiency in Primary and Established Myoblasts
Published in:
Molecular Therapy, 2002, v. 5, n. 2, p. 161, doi. 10.1006/mthe.2002.0528
By:
- Pampinella, Francesca;
- Lechardeur, Delphine;
- Zanetti, Elena;
- MacLachlan, Ian;
- Benharouga, Mohammed;
- Lukacs, Gergely L.;
- Vitiello, Libero
Publication type:
Article
Control of membrane protein homeostasis by a chaperone-like glial cell adhesion molecule at multiple subcellular locations.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97777-4
By:
- Xu, Haijin;
- Isenmann, Sandra;
- López-Hernández, Tania;
- Estévez, Raúl;
- Lukacs, Gergely L.;
- Apaja, Pirjo M.
Publication type:
Article
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
Published in:
Science Translational Medicine, 2014, v. 6, n. 246, p. 1, doi. 10.1126/scitranslmed.3008889
By:
- Veit, Guido;
- Avramescu, Radu G.;
- Perdomo, Doranda;
- Puay-Wah Phuan;
- Bagdany, Miklos;
- Apaja, Pirjo M.;
- Borot, Florence;
- Szollosi, Daniel;
- Yu-Sheng Wu;
- Finkbeiner, Walter E.;
- Hegedus, Tamas;
- Verkman, Alan S.;
- Lukacs, Gergely L.
Publication type:
Article
Epithelial Anion Transport as Modulator of Chemokine Signaling.
Published in:
Mediators of Inflammation, 2016, p. 1, doi. 10.1155/2016/7596531
By:
- Schnúr, Andrea;
- Hegyi, Péter;
- Rousseau, Simon;
- Lukacs, Gergely L.;
- Veit, Guido
Publication type:
Article
Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.
Published in:
PLoS Biology, 2016, v. 14, n. 5, p. 1, doi. 10.1371/journal.pbio.1002462
By:
- Veit, Guido;
- Oliver, Kathryn;
- Apaja, Pirjo M.;
- Perdomo, Doranda;
- Bidaud-Meynard, Aurélien;
- Lin, Sheng-Ting;
- Guo, Jingyu;
- Icyuz, Mert;
- Sorscher, Eric J.;
- Hartman IV, John L.;
- Lukacs, Gergely L.
Publication type:
Article
A Christianson syndrome-linked deletion mutation (Δ287 ES288) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death.
Published in:
Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0129-9
By:
- Ilie, Alina;
- Gao, Andy Y. L.;
- Reid, Jonathan;
- Boucher, Annie;
- McEwan, Cassandra;
- Barrière, Hervé;
- Lukacs, Gergely L.;
- McKinney, R. Anne;
- Orlowski, John
Publication type:
Article
New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.
Published in:
Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 2, p. 343, doi. 10.1002/pro.3086
By:
- Premchandar, Aiswarya;
- Kupniewska, Anna;
- Bonna, Arkadiusz;
- Faure, Grazyna;
- Fraczyk, Tomasz;
- Roldan, Ariel;
- Hoffmann, Brice;
- Faria da Cunha, Mélanie;
- Herrmann, Harald;
- Lukacs, Gergely L.;
- Edelman, Aleksander;
- Dadlez, Michał
Publication type:
Article
The?F508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.
Published in:
Nature Structural & Molecular Biology, 2005, v. 12, n. 1, p. 17, doi. 10.1038/nsmb882
By:
- Du, Kai;
- Sharma, Manu;
- Lukacs, Gergely L.
Publication type:
Article
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.
Published in:
2005
By:
- Pedemonte, Nicoletta;
- Lukacs, Gergely L;
- Du, Kai;
- Caci, Emanuela;
- Zegarra-Moran, Olga;
- Galietta, Luis J V;
- Verkman, A S
Publication type:
journal article
Small-molecule correctors of defective F508-CFTR cellular processing identified by high-throughput screening.
Published in:
Journal of Clinical Investigation, 2005, v. 115, n. 9, p. 2564, doi. 10.1172/JCI24898
By:
- Pedemonte, Nicoletta;
- Lukacs, Gergely L.;
- Du, Kai;
- Caci, Emanuela;
- Zegarra-Moran, Olga;
- Galietta, Luis J. V.;
- Verkman, A. S.
Publication type:
Article
Mutation-specific downregulation of CFTR2 variants by gating potentiators.
Published in:
Human Molecular Genetics, 2017, v. 26, n. 24, p. 4873, doi. 10.1093/hmg/ddx367
By:
- Avramescu, Radu G.;
- Yukari Kai;
- Haijin Xu;
- Bidaud-Meynard, Aurélien;
- Schnúr, Andrea;
- Frenkiel, Saul;
- Matouk, Elias;
- Veit, Guido;
- Lukacs, Gergely L.
Publication type:
Article

Found: 39

PINK1 autophosphorylation is required for ubiquitin recognition.

A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants.

Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells.

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.

COOH-terminal Truncations Promote Proteasome-dependent Degradation of Mature Cystic Fibrosis...

Importin 13 Regulates Nuclear Import of the Glucocorticoid Receptor in Airway Epithelial Cells.

Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines.

Discovery of novel potent ΔF508- CFTR correctors that target the nucleotide binding domain.

Quality control for unfolded proteins at the plasma membrane.

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic.

Site-specific ubiquitination exposes a linear motif to promote interferon-α receptor endocytosis.

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.

Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression.

Identification of Allosteric Inhibitors against Active Caspase-6.

Introduction / Introduction.

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca<sup>2+</sup>-induced proteostasis disease stress.

Mechanism-based corrector combination restores ΔF508-CFTR folding and function.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Analysis of AlphaMissense data in different protein groups and structural context.

Readthrough-induced misincorporated amino acid ratios guide mutant-specific therapeutic approaches for two CFTR nonsense mutations.

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl<sup>−</sup> channel function and trafficking.

Molecular Basis of Oligoubiquitin-Dependent Internalization of Membrane Proteins in Mammalian Cells.

Dominant and Recessive Distal Renal Tubular Acidosis Mutations of Kidney Anion Exchanger 1 Induce Distinct Trafficking Defects in MDCK Cells.

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents.

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect.

Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects.

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

Analysis of Differential Lipofection Efficiency in Primary and Established Myoblasts

Control of membrane protein homeostasis by a chaperone-like glial cell adhesion molecule at multiple subcellular locations.

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Epithelial Anion Transport as Modulator of Chemokine Signaling.

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.

A Christianson syndrome-linked deletion mutation (Δ<sup>287</sup> ES<sup>288</sup>) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death.

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

The?F508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Small-molecule correctors of defective F508-CFTR cellular processing identified by high-throughput screening.

Mutation-specific downregulation of CFTR2 variants by gating potentiators.