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- Title
Kinetics of CAR-T cells and immunological profile after tisagenlecleucel therapy.
- Authors
Richert-Przygońska, Monika; Stankiewicz, Joanna; Czyżewski, Krzysztof; Dębski, Robert; Kubicka, Małgorzata; Kuryło-Rafińska, Beata; Majk, Agnieszka; 1,Łukasz Ledziński, Ewa Dembna; Marquardt, Ewa; Gągola, Katarzyna; Styczyński, Jan
- Abstract
The article reports the case of a 5-year-old girl with primary refractory ALL who was treated with CAR-T cells. The patient experienced grade I CRS and grade II ICANS, which were successfully treated with tocilizumab and dexamethasone. The article discusses the monitoring of kinetics of CAR-T cells and cytokine profile, and the role of TNF-α in the development of CRS and ICAN.
- Subjects
MEDICAL ethics; TUMOR necrosis factors; MEDICAL societies; LEUCOCYTES; TREATMENT effectiveness
- Publication
Acta Haematologica Polonica, 2023, Vol 54, Issue 3, p195
- ISSN
0001-5814
- Publication type
Case Study
- DOI
10.5603/AHP.a2023.0031