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- Title
Safety assessment and diagnostic evaluation of patients undergoing contrast-enhanced urosonography in the setting of vesicoureteral reflux confirmation.
- Authors
Marschner, Constantin A.; Schwarze, Vincent; Stredele, Regina; Froelich, Matthias F.; Rübenthaler, Johannes; Geyer, Thomas; Clevert, Dirk-André; Küpper, J.-H.; Krüger-Genge, A.; Jung, F.
- Abstract
BACKGROUND: Vesicoureteral reflux (VUR) represents a common pediatric anomaly in children with an upper urinary tract infection (UTI) and is defined as a retrograde flow of urine from the bladder into the upper urinary tract. There are many diagnostic options available, including voiding cystourethrography (VCUG) and contrasted-enhanced urosonography (ceVUS). ceVUS combines a diagnostic tool with a high sensitivity and specificity which, according to previous study results, was even shown to be superior to VCUG. Nevertheless, despite the recommendation of the EFSUMB, the ceVUS has not found a widespread use in clinical diagnostics in Europe yet. MATERIALS AND METHODS: Between 2016 and 2020, 49 patients with a marked female dominance (n = 37) were included. The youngest patient had an age of 5 months, the oldest patient 60 years. The contrast agent used in ceVUS was SonoVue®, a second-generation blood-pool agent. All examinations were performed and interpreted by a single experienced radiologist (EFSUMB Level 3). RESULTS: The 49 patients included in the study showed no adverse effects. 51% of patients (n = 26) were referred with the initial diagnosis of suspected VUR, while 49% of patients (n = 23) came for follow-up examination or to rule out recurrence of VUR. The vast majority had at least one febrile urinary tract infection in their recent medical history (n = 45; 91,8%). CONCLUSION: ceVUS is an examination method with a low risk profile which represents with its high sensitivity and specificity an excellent diagnostic tool in the evaluation of vesicoureteral reflux, especially in consideration of a generally very young patient cohort.
- Subjects
EUROPE; URINARY tract infections; VESICO-ureteral reflux; ULTRASONIC imaging; CONTRAST media; BLADDER; SENSITIVITY &; specificity (Statistics); OLDER patients
- Publication
Clinical Hemorheology & Microcirculation, 2021, Vol 79, Issue 1, p65
- ISSN
1386-0291
- Publication type
Article
- DOI
10.3233/CH-219110