We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lamivudine monoprophylaxis for liver transplant recipients with non-replicating hepatitis B virus infection.
- Authors
Yoshida, Hideo; Kato, Tomoaki; Levi, David M.; Regev, Arie; Madariaga, Juan R.; Nishida, Seigo; Martinez, Enrique J.; Schiff, Eugene R.; Omata, Masao; Tzakis, Andreas G.
- Abstract
Background: The aim of this study was to evaluate the efficacy of lamivudine (LAM) monoprophylaxis for patients with non-replicating hepatitis B virus (HBV) infection at orthotopic liver transplantation (OLT). Methods: Among 128 liver recipients with HBV infection between 1994 and 2004 transplanted at our institution, 60 had non-replicating HBV infection at the time of OLT. Of those, 26 patients received LAM prophylaxis (monoprophylaxis group) and 34 patients received LAM and hepatitis B immunoglobulin (HBIG) prophylaxis (combination group) after OLT. Results: Median follow-up after OLT was 67 and 54 months, for monoprophylaxis and combination groups respectively. One and five yr patient/graft survival were 96/85% and 96/80% in monoprophylaxis group, and 85/79% and 67/55% in combination group. HBV DNA was re-detected or increased >105 IU/mL in four patients (15%) at 20–29 month in monoprophylaxis group and six (18%) at 4–35 months in combination group. Recurrent hepatitis was seen in two patients (8%) at 27 and 45 months and monoprophylaxis group and three (9%) at 21–35 months in combination group. The rate of recurrence was not statistically different between two groups. Conclusion: LAM monoprophylaxis seemed to be effective for OLT recipients with HBV infection who had non-replicating HBV at transplantation. HBIG administration may play a less valuable role in preventing HBV recurrence in this group of patients.
- Subjects
LIVER transplantation; HEPATITIS B virus; VIRUS diseases; IMMUNOGLOBULINS; VIRAL replication
- Publication
Clinical Transplantation, 2007, Vol 21, Issue 2, p166
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1111/j.1399-0012.2006.00557.x