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- Title
The synergetic effect of sitafloxacin–arbekacin combination in the Mycobacterium abscessus species.
- Authors
Watanabe, Junko; Ihara, Hiroaki; Takei, Satomi; Nakamura, Ayako; Fujimoto, Yuichi; Handoh, Tetsuya; Kurokawa, Kana; Arai, Yuta; Shibayama, Kohei; Sumiyoshi, Issei; Ochi, Yusuke; Okabe, Takahiro; Misawa, Shigeki; Togo, Shinsaku; Naito, Toshio; Tabe, Yoko; Miida, Takashi; Takahashi, Kazuhisa
- Abstract
Mycobacterium abscessus species (MABS) is the most commonly isolated rapidly growing mycobacteria (RGM) and is one of the most antibiotic-resistant RGM with rapid progression, therefore, treatment of MABS is still challenging. We here presented a new combination treatment with sitafloxacin that targeted rough morphotypes of MABS, causing aggressive infections. Thirty-four clinical strains of MABS were isolated from various clinical samples at the Juntendo university hospital from 2011 to 2020. The susceptibility to a combination of sitafloxacin and antimicrobial agents was compared to that of the antimicrobial agents alone. Out of 34 MABS, 8 strains treated with sitafloxacin–amikacin combination, 9 of sitafloxacin–imipenem combination, 19 of sitafloxacin–arbekacin combination, and 9 of sitafloxacin–clarithromycin combination showed synergistic effects, respectively. Sitafloxacin–arbekacin combination also exhibited the synergistic effects against 10 of 22 Mycobacterium abscessus subspecies massiliense (Mma) strains and 8 of 11 Mycobacterium abscessus subspecies abscessus (Mab) strains, a highly resistant subspecies of MABS. The sitafloxacin–arbekacin combination revealed more synergistic effects in rough morphotypes of MABS (p = 0.008). We demonstrated the synergistic effect of the sitafloxacin–arbekacin combination against MABS. Further, this combination regimen might be more effective against Mab or rough morphotypes of MABS.
- Subjects
AMIKACIN; MYCOBACTERIUM; SPECIES; ANTI-infective agents; MYCOBACTERIA; UNIVERSITY hospitals
- Publication
Scientific Reports, 2023, Vol 13, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-023-29021-0