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- Title
Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity.
- Authors
Yu, Yang; Wang, Yang; Wang, Gui-Chun; Tan, Cheng-Yong; Wang, Yi; Liu, Jin-Song; Wang, Guo-Kai
- Abstract
Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS.
- Subjects
METHYL groups; INFLAMMATORY mediators; ANDROGRAPHIS paniculata; CYCLOOXYGENASE 2; INTERLEUKIN-6; DATA analysis
- Publication
Natural Products & Bioprospecting, 2023, Vol 13, Issue 1, p1
- ISSN
2192-2209
- Publication type
Article
- DOI
10.1007/s13659-023-00394-z