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- Title
The CD28/HLA-DR expressions on CD4<sup>+</sup> T but not CD8<sup>+</sup> T cells are significant predictors for progression to AIDS.
- Authors
Choi, Byeong-Sun; Park, Yong-Keun; Lee, Joo-Shil
- Abstract
SUMMARY To investigate the changes of CD28 and HLA-DR molecules on CD4+ and CD8+ T cells during HIV infection, we classified 130 HIV-infected Koreans into four groups by the CD4 level as follows: group I (≥500 cells/mm3 ), group II (201–499 cells/mm3 ), group III (51–200 cells/mm3 ), and group IV (≤50 cells/mm3 ). In CD4+ T cells, the proportion of CD28 expression decreased significantly with the CD4 level while the proportion of HLA-DR expression increased gradually. In particular, the changes of HLA-DR expressions on CD4+ T cells were parallel to the loss of CD28 molecules from stage III to IV. However, the CD28 expression on CD8+ T cells decreased dramatically in the early stage of HIV infection, and the sum and pattern of CD28 and HLA-DR expressions on CD8+ T cells was stable after the first stage. Even though CD28 down-regulation on CD8+ T cells was very severe from the early stage of HIV infection, it might not influence the survival time of HIV-infected Koreans. The sum of the CD28+ subsets and HLA-DR subsets in each T cell was stable in all stages of disease progression. The sums of the CD28+ subsets and HLA-DR+ subsets in CD4+ T and CD8+ T cells were constant as approximately 100% and 55–60% of each T cell. These results suggested that the changes of CD28/HLA-DR expressions on CD4+ T cells were more predictable than those on CD8+ T cells in the evaluation of the disease progression during HIV-infected periods. However, we need further studies to understand why the sum of two molecules in each T cell are constant.
- Subjects
SOUTH Korea; HLA histocompatibility antigens; T cells; HIV infections
- Publication
Clinical & Experimental Immunology, 2002, Vol 127, Issue 1, p137
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1046/j.1365-2249.2002.01732.x