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- Title
Relationship between IL-1beta gene polymorphism and gastric mucosal IL-1beta levels in patients with Helicobacter pylori infection.
- Authors
Xuan J; Deguchi R; Watanabe S; Ozawa H; Urano T; Ogawa Y; Fukuda R; Kijima H; Koga Y; Takagi A; Xuan, Jiang; Deguchi, Ryuzo; Watanabe, Sumio; Ozawa, Hideki; Urano, Tetsuya; Ogawa, Yoshiaki; Fukuda, Ryuki; Kijima, Hiroshi; Koga, Yasuhiro; Takagi, Atsushi
- Abstract
<bold>Background: </bold>Interkeukin-1 (IL-1) gene cluster polymorphisms that are thought to enhance the production of IL-1beta are associated with an increased risk of gastric cancer. To determine the role of host genetic factors in Helicobacter pylori infection, we examined the relationship between gastric mucosal IL-1beta levels and IL-1B polymorphisms in patients with H. pylori infection.<bold>Methods: </bold>Biopsy tissues obtained from 99 patients were homogenized and gastric mucosal IL-1beta levels were measured by enzyme-linked immunosorbent assay (ELISA). Single-base polymorphisms at positions -511 and -31 in IL-1B were analyzed.<bold>Results: </bold>The IL-1beta level in the antrum was significantly higher in genotype IL-1B-511C/C than in H. pylori-negative patients (P < 0.05). The IL-1B polymorphism did not influence the degree of gastric neutrophil and mononuclear cell infiltration, or gastric atrophy. IL-1beta levels in the corpus, but not those in the antrum, correlated to the severity of gastric atrophy.<bold>Conclusions: </bold>These findings indicate that IL-1B polymorphisms enhance IL-1beta production in the antrum; however, other factors might regulate the production of IL-1beta in the corpus of the stomach, regardless of IL-1B polymorphisms, and high IL-1beta production may be associated with the grade of gastric atrophy in the corpus mucosa in patients with H. pylori infection.
- Publication
Journal of Gastroenterology, 2005, Vol 40, Issue 8, p796
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s00535-005-1630-z