We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection.
- Authors
Yang, Jing; Huang, Xinmei; Liu, Yuzhuo; Zhao, Dongmin; Han, Kaikai; Zhang, Lijiao; Li, Yin; Liu, Qingtao
- Abstract
MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
- Subjects
AVIAN influenza A virus; DENDRITIC cells; VIRUS diseases; MICRORNA; PATHOLOGY; ENDOCYTOSIS; P53 protein; LYSOSOMES
- Publication
Veterinary Research, 2020, Vol 51, Issue 1, pN.PAG
- ISSN
0928-4249
- Publication type
Article
- DOI
10.1186/s13567-020-00856-z