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Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4- d ]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme.
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- Pharmaceutics, 2023, v. 15, n. 2, p. 453, doi. 10.3390/pharmaceutics15020453
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- Article
Identification and Biological Characterization of the Pyrazolo[3,4- d ]pyrimidine Derivative SI388 Active as Src Inhibitor.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 7, p. 958, doi. 10.3390/ph16070958
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- Article
Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis.
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- Brain: A Journal of Neurology, 2023, v. 146, n. 12, p. 5060, doi. 10.1093/brain/awad240
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- Article
High Flexibility of RNaseH2 Catalytic Activity with Respect to Non-Canonical DNA Structures.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 10, p. 5201, doi. 10.3390/ijms22105201
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- Article
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 5, p. 2365, doi. 10.3390/ijms22052365
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- Article
How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?
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- Biochemical Journal, 2017, v. 474, n. 10, p. 1559, doi. 10.1042/BCJ20160772
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- Article
A new proofreading mechanism for lesion bypass by DNA polymerase-λ.
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- EMBO Reports, 2012, v. 13, n. 1, p. 68, doi. 10.1038/embor.2011.226
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- Article
p15PAF binding to PCNA modulates the DNA sliding surface.
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- Nucleic Acids Research, 2018, v. 46, n. 18, p. 9816, doi. 10.1093/nar/gky723
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- Article
Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.
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- Nucleic Acids Research, 2017, v. 45, n. 5, p. 2600, doi. 10.1093/nar/gkw1275
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- Article
Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences.
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- Nucleic Acids Research, 2012, v. 40, n. 13, p. 5577, doi. 10.1093/nar/gks186
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- Article
Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences.
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- Nucleic Acids Research, 2012, v. 40, n. 12, p. 5577, doi. 10.1093/nar/gks186
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- Article
Error-free bypass of 2-hydroxyadenine by human DNA polymerase λ with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts.
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- Nucleic Acids Research, 2007, v. 35, n. 15, p. 5173, doi. 10.1093/nar/gkm568
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- Article
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases β and λ.
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- Nucleic Acids Research, 2007, v. 35, n. 1, p. 45
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- Article
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect.
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- ChemMedChem, 2022, v. 17, n. 17, p. 1, doi. 10.1002/cmdc.202200277
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- Article
Front Cover: Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses (ChemMedChem 23/2021).
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- ChemMedChem, 2021, v. 16, n. 23, p. 3495, doi. 10.1002/cmdc.202100724
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- Article
Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses.
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- ChemMedChem, 2021, v. 16, n. 23, p. 3548, doi. 10.1002/cmdc.202100483
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- Article
Cover Feature: Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds (ChemMedChem 14/2018).
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- ChemMedChem, 2018, v. 13, n. 14, p. 1370, doi. 10.1002/cmdc.201800443
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- Article
Identification of Broad‐Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6‐Diaminopurine Scaffolds.
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- ChemMedChem, 2018, v. 13, n. 14, p. 1371, doi. 10.1002/cmdc.201800178
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- Article
The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides.
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- Proteins, 2008, v. 71, n. 2, p. 715, doi. 10.1002/prot.21829
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- Article
8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins.
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- Nature, 2007, v. 447, n. 7144, p. 606, doi. 10.1038/nature05843
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- Article
Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase λ and Proliferating Cell Nuclear Antigen 2.
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- Plant Cell, 2011, v. 23, n. 2, p. 806, doi. 10.1105/tpc.110.081455
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- Article
Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases β and λ.
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- Nucleic Acids Research, 2005, v. 33, n. 13, p. 4117, doi. 10.1093/nar/gki723
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- Article
Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair.
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- Nature Communications, 2016, v. 7, n. 2, p. 10805, doi. 10.1038/ncomms10805
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- Article
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action.
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- Angewandte Chemie, 2010, v. 122, n. 10, p. 1849, doi. 10.1002/ange.200905651
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- Article
Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops.
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- Nucleic Acids Research, 2024, v. 52, n. 19, p. 11641, doi. 10.1093/nar/gkae731
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- Article
Selective Binding and Redox-Activity on Parallel G-Quadruplexes by Pegylated Naphthalene Diimide-Copper Complexes.
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- Molecules, 2021, v. 26, n. 16, p. 5025, doi. 10.3390/molecules26165025
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- Article
Exploiting the Nucleotide Substrate Specificity of Repair DNA Polymerases To Develop Novel Anticancer Agents.
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- Molecules, 2011, v. 16, n. 9, p. 7994, doi. 10.3390/molecules16097994
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- Article
Tyrosine Kinase Inhibitor Si409 Has In Vitro and In Vivo Anti-Tumor Activity Against Diffuse Large B-Cell Lymphoma.
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- Pharmaceutical Chemistry Journal, 2023, v. 56, n. 12, p. 1616, doi. 10.1007/s11094-023-02836-x
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- Article
DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair.
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- Genes, 2016, v. 7, n. 9, p. 57, doi. 10.3390/genes7090057
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- Article
Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents.
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- ChemMedChem, 2013, v. 8, n. 8, p. 1353, doi. 10.1002/cmdc.201300204
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- Article
A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors.
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- ChemMedChem, 2013, v. 8, n. 3, p. 484, doi. 10.1002/cmdc.201200480
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- Article
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl.
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- ChemMedChem, 2011, v. 6, n. 11, p. 2009, doi. 10.1002/cmdc.201100304
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- Article
3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors.
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- ChemMedChem, 2009, v. 4, n. 6, p. 976, doi. 10.1002/cmdc.200800441
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- Article
Slow-, Tight-Binding HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants.
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- ChemMedChem, 2007, v. 2, n. 4, p. 445, doi. 10.1002/cmdc.200600310
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- Article
Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2).
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- ChemMedChem, 2006, v. 1, n. 12, p. 1379, doi. 10.1002/cmdc.200600122
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- Article
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action.
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- Angewandte Chemie International Edition, 2010, v. 49, n. 10, p. 1805, doi. 10.1002/anie.200905651
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- Article