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- Title
Effects of Astaxanthin Supplementation on Fatigue, Motor Function and Cognition: A Meta-Analysis of Randomized Controlled Trials.
- Authors
Liu, Changjiang; Dong, Xiaoling; Jia, Jia; Ha, Mei
- Abstract
Dietary astaxanthin supplementation has been demonstrated to have many beneficial and health-promoting effects. The purpose of this systematic review and meta-analysis was to assess the effect of astaxanthin supplementation on fatigue, cognition, and exercise efficiency. A total of 11 randomized controlled trials (RCTs) with 346 healthy participants were included. The random effects model and pooled standardized mean difference (SMDs) were used according to Hedge's g for the meta-analysis, and a meta-regression was also conducted. The results of the two existing studies showed a positive trend for astaxanthin in subjective fatigue relief. The effects of astaxanthin supplementation for 8–12 weeks on cognitive accuracy were marginally significant (SMD:.12; 95% CI: −.02–.26) and on reaction time was not significant (SMD: −.08; 95% CI: −.26 to.10). Remarkably, astaxanthin supplementation combined with regular training could enhance the fat oxidation (SMD: 2.56; 95% CI: 1.24–3.89), and significantly improve the physical performance (SMD:.62; 95% CI:.17–1.06). The subgroup analysis further showed significantly greater benefits when performing the aerobic exercises performance (SMD:.45; 95% CI:.13–.76), when the dose was ≥ 20 mg (SMD:.37; 95% CI:.11–.63), and when the supplementation duration was > 12 weeks (SMD:.66; 95% CI:.13–.63). We conclude that astaxanthin supplementation could significantly enhance aerobic exercise efficiency, especially at higher doses and for longer durations. Further studies based on large sample sizes are imperatively warranted.
- Subjects
MOTOR ability; MEDICAL information storage &; retrieval systems; RESEARCH funding; CAROTENOIDS; FATIGUE (Physiology); CINAHL database; META-analysis; DESCRIPTIVE statistics; AEROBIC capacity; SYSTEMATIC reviews; MEDLINE; ANTIOXIDANTS; MEDICAL databases; AEROBIC exercises; BODY movement; ONLINE information services; CONFIDENCE intervals; DIETARY supplements; COGNITION; PSYCHOLOGY information storage &; retrieval systems
- Publication
Biological Research for Nursing, 2024, Vol 26, Issue 3, p469
- ISSN
1099-8004
- Publication type
Article
- DOI
10.1177/10998004241227561