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- Title
Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus.
- Authors
McCarthy, Molly E.; Oltman, Scott P.; Jelliffe‐Pawlowski, Laura L.; Baer, Rebecca J.; Ryckman, Kelli K.; Rogers, Elizabeth E.; Steurer‐Muller, Martina A.; Witte, John S.
- Abstract
Our objective was to assess the relationship between hyperbilirubinemia with and without kernicterus and metabolic profile at newborn screening. Included were 1,693,658 infants divided into a training or testing subset in a ratio of 3:1. Forty‐two metabolites were analyzed using logistic regression (odds ratios (ORs), area under the receiver operating characteristic curve (AUC), 95% confidence intervals (CIs)). Several metabolite patterns remained consistent across gestational age groups for hyperbilirubinemia without kernicterus. Thyroid stimulating hormone (TSH) and C‐18:2 were decreased, whereas tyrosine and C‐3 were increased in infants across groupings. Increased C‐3 was also observed for kernicterus (OR: 3.17; 95% CI: 1.18–8.53). Thirty‐one metabolites were associated with hyperbilirubinemia without kernicterus in the training set. Phenylalanine (OR: 1.91; 95% CI: 1.85–1.97), ornithine (OR: 0.76; 95% 0.74–0.77), and isoleucine + leucine (OR: 0.63; 95% CI: 0.61–0.65) were the most strongly associated. This study showed that newborn metabolic function is associated with hyperbilirubinemia with and without kernicterus.
- Subjects
NEWBORN infants; METABOLIC profile tests; HYPERBILIRUBINEMIA; KERNICTERUS; PHENYLALANINE
- Publication
CTS: Clinical & Translational Science, 2019, Vol 12, Issue 1, p28
- ISSN
1752-8054
- Publication type
Article
- DOI
10.1111/cts.12590