We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antibody-Independent Control of γ-Herpesvirus Latency via B Cell Induction of Anti-Viral T Cell Responses.
- Authors
McClellan, Kelly B.; Gangappa, Shivaprakash; Speck, Samuel H.; Virgin IV, Herbert W.; McFadden, Grant
- Abstract
B cells can use antibody-dependent mechanisms to control latent viral infections. It is unknown whether this represents the sole function of B cells during chronic viral infection. We report here that hen egg lysozyme (HEL)-specific B cells can contribute to the control of murine γ-herpesvirus 68 (γHV68) latency without producing anti-viral antibody. HEL-specific B cells normalized defects in T cell numbers and proliferation observed in B cell−/− mice during the early phase of γHV68 latency. HEL-specific B cells also reversed defects in CD8 and CD4 T cell cytokine production observed in B cell−/− mice, generating CD8 and CD4 T cells necessary for control of latency. Furthermore, HEL-specific B cells were able to present virally encoded antigen to CD8 T cells. Therefore, B cells have antibody independent functions, including antigen presentation, that are important for control of γ-herpesvirus latency. Exploitation of this property of B cells may allow enhanced vaccine responses to chronic virus infection.
- Subjects
IMMUNE response; ANTIGEN-antibody reactions; B cells; ANTIGEN presenting cells; HERPESVIRUS diseases; LATENT infection; VACCINES; PREVENTION; THERAPEUTICS
- Publication
PLoS Pathogens, 2006, Vol 2, Issue 6, pe58
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.0020058