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- Title
SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF SOME NEW N AND S-ALKYLATED ARYLIDENE-THIOXO-IMIDAZOLIDINONES.
- Authors
Santos, L. C.; Mourã o, R. H. V.; Uchoa, F. T.; Silva, T. G.; Malta, D. J. N.; Moura, R. O.; Lima, M. C. A.; Galdino, S. L.; Pitta, I. R.; Barbe, J.
- Abstract
New arylidene-thioxo-imidazolidinones and S-alkylated arylidene-imidazolidinone derivatives were prepared from substituted 2-thioxo-imidazolidin-4-one by nucleophilic addition of cyanoacrylates. N and S-alkylation was achieved treating 5-arylidene-2-thioxo-imidazolidin-4-ones with benzyl or phenyloxoethyl chlorides under alkaline conditions. The anti-inflammatory activity of the synthesized imidazolidines was evaluated by the air pouch test and the carrageenan-induced paw edema test.
- Publication
Heterocyclic Communications, 2005, Vol 11, Issue 5, p433
- ISSN
0793-0283
- Publication type
Article