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- Title
Formulation, Optimization and Characterization of Microspheres using Biomaterial Arabinoxylan.
- Authors
SHUJAAT, JOHAR; ERUM, ALIA; TULAIN, UME-RUQIA; NOREEN, SOBIA; ISMAIL, ASMARA
- Abstract
Microspheres of new biomaterial arabinoxylan loaded with levosulpiride a model drug were formulated using ionotropic gelation technique. Microspheres were optimized by using different reaction parameters like cross linkers type and concentrations, concentration of biomaterial arabinoxylan, effect of reaction temperature and reaction time and drug loading method. Nine different formulations were formulated. It was observed that best microspheres were formulated using 10 % CaCl2, 3 % arabinoxyaln at 600C temperature and 15 minutes reaction time for curing. Compatibility of arabinoxylan with levosulpiride was tested by using XRD and FTIR techniques. Microsphere formulations were evaluated for percentage yield, flow properties, swelling index, solvent regain and drug release studies. Formulations possessed excellent flow properties as indicated by their angle of repose, Carr's index, Hausner's ratio, tapped density and bulk density. SEM showed that microspheres were almost spherical and had rough surface morphology. Levosulpiride release from biomaterial arabinoxylan followed Korsmeyer-Peppas model showing drug release by diffusion and erosion of polymer. So this study provides a scientific evidence for the use of arabinoxylan as an effective alternative to sodium alginate for microsphere formulation.
- Subjects
MICROSPHERES; ARABINOXYLANS; CROSSLINKED polymers; X-ray diffraction; FOURIER transform infrared spectroscopy
- Publication
Journal of Polymer Materials, 2017, Vol 34, Issue 4, p809
- ISSN
0973-8622
- Publication type
Article