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- Title
Surgical Management of High-Grade Meningiomas.
- Authors
Pacult, Mark A.; Przybylowski, Colin J.; Raza, Shaan M.; DeMonte, Franco
- Abstract
Simple Summary: Meningiomas are classified pathologically by the World Health Organization (WHO) grading system, with WHO grade 2 and 3 tumors considered "high-grade". These tumors are characterized microscopically by high mitotic rates and macroscopically by a brain invasion. The goal of the surgical treatment of these tumors is maximal safe resection to minimize surgical morbidity and extend patient survival. Surgical resection is made difficult by frequently indistinct boundaries between normal brain layers and the encasement of blood vessels and cranial nerves. Surgeons and scientists must continue to collaborate to offer patients the highest quality operative and post-operative medical care. Maximal resection with the preservation of neurological function are the mainstays of the surgical management of high-grade meningiomas. Surgical morbidity is strongly associated with tumor size, location, and invasiveness, whereas patient survival is strongly associated with the extent of resection, tumor biology, and patient health. A versatile microsurgical skill set combined with a cogent multimodality treatment plan is critical in order to achieve optimal patient outcomes. Continued refinement in surgical techniques in conjunction with directed radiotherapeutic and medical therapies will define future treatment.
- Subjects
CANCER invasiveness; RADIOTHERAPY; TUMOR grading; TREATMENT effectiveness; CYTOREDUCTIVE surgery; CANCER patients; OPERATIVE surgery; SURGICAL margin; MENINGIOMA; PERIOPERATIVE care; SURGICAL technology; OVERALL survival; HISTOLOGY
- Publication
Cancers, 2024, Vol 16, Issue 11, p1978
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16111978