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- Title
Recent advances in catalysts for the Henry reaction.
- Authors
Bao, Xuefei; Li, Xu; Jiang, Chunfeng; Xiao, Wei; Chen, Guoliang
- Abstract
The Henry reaction, the coupling of a nitro alkane and a carbonyl group, is an important C–C bond-forming reaction giving nitro alkanols, which are useful, versatile intermediates in synthetic organic chemistry and for the pharmaceutical industry. Among the catalysts employed in the Henry reaction, transition metal complex catalysts play an important role. Transition metal complexes, including small molecules and nanoparticles, catalyze the asymmetric Henry reaction efficiently and in most of the cases give chiral nitro alkanol products in good yield and enantiomeric excess. This review summarizes transition metal complex catalysts, metal-free organic catalysts and nanoparticle catalysts for the Henry reaction. The Henry reaction is an important C–C bond-forming reaction giving nitro alkanols, which are useful versatile intermediates in synthetic organic chemistry and the pharmaceutical industry. Among the catalysts employed in the Henry reaction, transition metal complexes and nanoparticles play an important role. This review summarizes the transition metal complex catalysts, metal-free organic catalysts and nanoparticle catalysts for the Henry reaction reported since 2020.
- Subjects
TRANSITION metal catalysts; ORGANIC synthesis; TRANSITION metal complexes; CATALYSTS; PHARMACEUTICAL chemistry; METAL nanoparticles; NITROALDOL reactions
- Publication
Australian Journal of Chemistry, 2022, Vol 75, Issue 10, p806
- ISSN
0004-9425
- Publication type
Article
- DOI
10.1071/CH22136