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- Title
Molecularly Imprinted Polymer Based Chemiluminescence Method for Detection of Nitrofurans.
- Authors
Zhang, Xin-Ying; Liu, Ju-Xiang; Jiang, Zu-Qiang; Wang, Jian-Ping
- Abstract
In this study, a molecularly imprinted polymer capable of simultaneously recognising seven nitrofurans is synthesised. The polymer particles coated the wells of a conventional 96-well microplate as the recognition element. After sample loading, the analytes were absorbed and a highly sensitive imidazole-enhanced bis(2,4,6-trichlorophenyl) oxalate–H2O2 system was added to excite light emission. After optimisation of several parameters, the chemiluminescence method was used to determine the seven nitrofurans in animal feeds. Results showed that the method achieved ultrahigh sensitivity for the seven drugs with limits of detection of 5–12 pg mL−1, and one assay was finished within 10 min. In addition, the polymer-coated plate could be reused five times. The recoveries from the standard fortified blank feed samples were in the range of 74.8–97.4 %. From a comparison with a high performance liquid chromatography method, the molecularly imprinted polymer based chemiluminescence method could be used as a simple, rapid, sensitive, and recyclable tool to monitor the abuse of nitrofurans in animal feeds. The simplest way to monitor the abuse of nitrofurans is to analyse animal feeds. A class-specific molecularly imprinted polymer for nitrofurans is synthesised and used as a recognition reagent to prepare a chemiluminescence method for the determination of seven nitrofurans in animal feeds. The assay consists of only one sample loading step and can be reused five times.
- Subjects
CHEMILUMINESCENCE; NITROFURANS; POLYMERS
- Publication
Australian Journal of Chemistry, 2019, Vol 72, Issue 5, p375
- ISSN
0004-9425
- Publication type
Article
- DOI
10.1071/CH18616