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- Title
Central and peripheral fat and subclinical vascular damage in older women.
- Authors
Fantin, Francesco; Rossi, Andrea P.; Cazzadori, Marco; Comellato, Gabriele; Mazzali, Gloria; Gozzoli, Maria Paola; Grison, Elisa; Zamboni, Mauro
- Abstract
Objective: the aim of this study was to evaluate the relationship between fat distribution and arterial compliance in a group of elderly women, in particular to test a possible independent role of abdominal fat mass and peripheral fat mass on subclinical vascular damage, defined by a pulse wave velocity (PWV) >12 m/s.Methods: in 96 women with age range 60–80 years (68.65 ± 4.98 years) and BMI range from 18.8 to 41.2 kg/m2 (27.07 ± 4.61 kg/m2), we evaluated the body mass index, waist circumference, systolic and diastolic blood pressure, fasting glucose, cholesterol, LDL and HDL cholesterol, triglycerides and body composition by dual energy X-ray absorptiometry (DXA). Arterial stiffness was assessed by carotid-femoral (PWVcf) and carotid-radial pulse wave velocity (PWVcr).Results: significant associations were found between PWVcf, age, waist circumference, BMI and trunk fat assessed by DXA, as well as TG and HDL cholesterol. After adjustment for the total fat mass a negative statistically significant association between PWVcf and leg fat mass was shown. In multiple regression analyses the mean arterial pressure, trunk fat mass and leg fat mass were significant predictors of vascular damage with OR, respectively, of 1.06 (CI: 1.01–1.11), 1.25 (CI: 1.06–1.48) and 0.73 (CI: 0.53–0.99).Conclusions: the results of this study show, in a sample of apparently healthy elderly women, that central and peripheral adiposity are independent predictors, with an opposite effect on subclinical vascular damage, confirming and strengthening the protective role of the gluteal-femoral fat on cardiovascular risk even in elderly.
- Subjects
ITALY; VASCULAR diseases; ADIPOSE tissues; ANALYSIS of variance; CONFIDENCE intervals; EPIDEMIOLOGY; PROBABILITY theory; REGRESSION analysis; STATISTICS; DATA analysis; BODY mass index; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics; ABDOMINAL adipose tissue; PHOTON absorptiometry; OLD age; DISEASE risk factors
- Publication
Age & Ageing, 2013, Vol 42, Issue 3, p359
- ISSN
0002-0729
- Publication type
Article
- DOI
10.1093/ageing/aft005