We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device.
- Authors
Hiroaki Hiraiwa; Takahiro Okumura; Shinya Shimizu; Yoshihito Arao; Hideo Oishi; Hiroo Kato; Tasuku Kuwayama; Shogo Yamaguchi; Tomoaki Haga; Tsuyoshi Yokoi; Toru Kondo; Yuki Sugiura; Naoaki Kano; Naoki Watanabe; Kenji Fukaya; Kenji Furusawa; Akinori Sawamura; Ryota Morimoto; Kazuro Fujimoto; Masato Mutsuga
- Abstract
We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.
- Subjects
MYOCARDIUM; HEART assist devices; CARDIOMYOPATHIES; ANTHRACYCLINES; BIOPSY; COLLAGEN; HEART cells
- Publication
Nagoya Journal of Medical Science, 2020, Vol 82, Issue 1, p129
- ISSN
0027-7622
- Publication type
Case Study
- DOI
10.18999/nagjms.82.1.129