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- Title
Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome.
- Authors
Van Den Eede, Filip; Moorkens, Greta; Van Houdenhove, Boudewijn; Cosyns, Paul; Claes, Stephan J.
- Abstract
There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS), despite the negative studies and methodological difficulties. In this review, we focus on challenge studies and on the role of the HPA axis in the pathogenesis of CFS. Mild hypocortisolism, blunted adrenocorticotropin response to stressors and enhanced negative feedback sensitivity to glucocorticoids are the main findings. Several underlying mechanisms have been proposed. Currently, it is a matter of debate whether these disturbances have a primary role in the pathogenesis of CFS. However, even if the HPA axis dysfunctions are secondary to other factors, they are probably a relevant factor in symptom propagation in CFS. Copyright © 2007 S. Karger AG, Basel
- Subjects
HYPOTHALAMIC-pituitary-adrenal axis; CHRONIC fatigue syndrome; ADRENOCORTICOTROPIC hormone; GLUCOCORTICOIDS; HYDROCORTISONE; CORTICOTROPIN releasing hormone; FATIGUE (Physiology); PSYCHOLOGICAL stress
- Publication
Neuropsychobiology, 2007, Vol 55, Issue 2, p112
- ISSN
0302-282X
- Publication type
Article
- DOI
10.1159/000104468