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- Title
Three-dimensional ultrasound cranial imaging and early neurodevelopment in preterm growth-restricted infants.
- Authors
McLean, Glenda; Hough, Catherine; Sehgal, Arvind; Ditchfield, Michael; Polglase, Graeme R.; Miller, Suzanne L.
- Abstract
<bold>Aim: </bold>Fetal growth restriction (FGR) is associated with increased perinatal morbidity, mortality and long-term neurodevelopmental sequelae. The objective of this study was to examine whether information about early neurodevelopmental deficits was evident using three-dimensional head ultrasound and developmental assessments in preterm infants with FGR, compared with appropriate for gestational age (AGA) infants in the early post-natal period.<bold>Methods: </bold>Twenty preterm FGR infants weighing <10th centile and born between 28 and 32 weeks were compared with age-matched AGA infants. In the second post-natal week after birth, we used three-dimensional ultrasound to assess cerebral ventricular volumes. Prechtl General Movement Assessments were performed at 4-6 weeks after birth. Test of Infant Motor Performance (TIMP) to measure functional motor behaviour was performed at 4-6 and 12-14 weeks corrected age.<bold>Results: </bold>There was no statistically significant difference in the combined cerebral ventricular volume between the two groups (FGR, 0.81 ± 0.42 vs. AGA 0.72 ± 0.38 cm3 , P = 0.4). The TIMP assessment at 12-14 week term corrected demonstrated lower scores (worse performance) in FGR infants compared with the AGA cohort (regression coefficient: -7.74 (95% CI -16.06, 0.57); P = 0.07). We observed a significant correlation between greater ventricular volume and lower TIMP scores in the cohorts separately and also overall (FGR, r = -0.5, P = 0.06 vs. AGA, r = -0.62, P = 0.007 and overall, r = -0.53, P = 0.001).<bold>Conclusion: </bold>Ultrasound in the early weeks may be useful to detect the neuropathology which could then mediate functional consequences.
- Subjects
THREE-dimensional imaging; NEURODEVELOPMENTAL treatment; PREMATURE infants; FETAL growth disorders; MORTALITY; GESTATIONAL age; ANTHROPOMETRY; BIRTH size; CEREBRAL ventricles; FETAL growth retardation; ULTRASONIC encephalography; CASE-control method
- Publication
Journal of Paediatrics & Child Health, 2018, Vol 54, Issue 4, p420
- ISSN
1034-4810
- Publication type
journal article
- DOI
10.1111/jpc.13808