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- Title
One Case of Drug-Resistant Invasive Fungal Infection after Myelodysplastic Syndrome Chemotherapy.
- Authors
Yingying Chen; Xinhong Yang; Xue Wu; Yingwei Wu; Yan Li
- Abstract
Background: The aim of this study was to evaluate the therapeutic regimen of a patient with myelodysplastic syndrome (MDS) who developed invasive fungal infections caused by drug-resistant Candida tropicalis after chemotherapy and to investigate the effect of drug treatment. Methods: We referred to the Diagnostic Criteria and Treatment Principles of invasive fungal diseases in patients with hematological diseases and malignant tumors (2013, fourth revised edition) and the Expert Consensus on Clinical Application of Posaconazole (2022 Edition). In addition, the drug treatment regimens of drug-resistant Candida tropicalis were reviewed. The doctors in charge were involved in the drug treatment process, and the rational drug use was selected according to evidence-based medicine. Results: After 4 months of use, the nodules around the body disappeared, and there was no further fever during follow-up. After 6 months of use, posaconazole was discontinued, and the patient continued to follow-up for 1 month without further fever or nodules. Conclusions: The combination of posaconazole, amphotericin B liposome, and micafungin is effective in the treatment of fluconazole-resistant Candida tropicalis infection.
- Subjects
MYELODYSPLASTIC syndromes; BLOOD diseases; MYCOSES; CANDIDA tropicalis; CANDIDIASIS; AMPHOTERICIN B; CANDIDEMIA
- Publication
Clinical Laboratory, 2024, Vol 70, Issue 6, p1166
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2023.231213