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- Title
Direct Synthesis of 3‐Arylphthalides Promoted by Eaton's reagent.
- Authors
Eddebbarh, Enzo; Moutardier, Léa; Thibonnet, Jérôme; Camiade, Emilie; Petrignet, Julien
- Abstract
A rapid method has been developed for the synthesis of 3‐arylphthalides from readily available starting materials. We describe herein a direct approach based on a simple Friedel‐Crafts condensation between an aromatic ester and an aldehyde promoted by a mixture of phosphorus pentoxide and methanesulfonic acid (Eaton's reagent) under metal and solvent‐free conditions. Due to their similarity to cytosporone E (a natural antibacterial phthalide), some of the synthesized compounds were tested as antibacterial agents against methicillin‐resistant strain of Staphylococcus aureus.
- Subjects
METHICILLIN-resistant staphylococcus aureus; PHOSPHORIC anhydride; CHEMICAL synthesis; ANTIBACTERIAL agents; AROMATIC aldehydes; METALS
- Publication
European Journal of Organic Chemistry, 2024, Vol 27, Issue 8, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202301303