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- Title
Tempol treatment shows phenotype improvement in mdx mice.
- Authors
Hermes, Túlio de Almeida; Mâncio, Rafael Dias; Macedo, Aline Barbosa; Mizobuti, Daniela Sayuri; Rocha, Guilherme Luiz da; Cagnon, Valéria Helena Alves; Minatel, Elaine
- Abstract
Considering potential Tempol effects on mdx muscle fibers, in this study we evaluated its effects on relevant dystrophic phenotypic characteristics, such as muscle degeneration, inflammatory process and angiogenesis, which as yet have not been investigated. Mdx mice were randomly assigned into three groups: mdxS, the control group receiving intraperitoneal (i.p.) injections of saline solution (100μL); mdxP, positive control group receiving prednisolone (1mg/kg) by oral gavage; and mdxT, treated group receiving i.p. injections of tempol (100 mg/kg). C57BL/10 mice were also used as controls. Tempol treatment promoted gain in muscle strength and reduced myonecrosis and inflammatory response in the dystrophic diaphragm (DIA) and biceps brachii (BB) muscles. No evidence of Tempol's beneficial performance on angiogenesis in DIA and BB mdx muscles was found. The findings presented here show that Tempol treatment improves dystrophic phenotype, supporting its use as a potential therapeutic strategy in DMD.
- Subjects
MUSCLE strength; SALINE injections; SALINE solutions; BICEPS brachii; INFLAMMATION; PHENOTYPES; MICE
- Publication
PLoS ONE, 2019, Vol 14, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0215590