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- Title
Correlation of Clinical Risk Factors with Diffusion-Weighted Magnetic Resonance Images in Prostate Cancer Patients Treated with Definitive Radiotherapy.
- Authors
ERBAY, Gurcan; ONAL, Cem; GULER, Ozan C.; KARADELI, Elif; KOC, Zafer
- Abstract
This study is aimed to correlate apparent diffusion coefficient (ADC) values and clinical T-stage, serum PSA, pathology Gleason scores. We also further analyzed whether ADC values could be used to appropriately define the risk groups. 135 biopsy-proven, radiotherapy-(RT)-treated, prostate cancer patients who underwent pre-RT DW-MRI and standard T2W pelvic MRI were included. ADC and normalized ADC (nADC) values were calculated from DW-MRI delivered a median 8.1 weeks after prostate biopsy. ADC values were correlated with clinical risk factor values by using Pearson correlation test. ADCs in low-, intermediate-, and high-risk patients were 0.873±0.122X10-3 mm2/s, 0.763±0.124X10-3 mm2/s, and 0.701±0.132X10-3 mm2/s (p= 0.001), respectively. Patients with preRT PSA <10 ng/mL had significantly higher ADCs than patients with preRT PSA 10-20 ng/mL (p= 0.02) or >20 ng/mL (p< 0.001). Mean ADC for patients with Gleason score <7 was significantly higher than patients scoring 7 (p= 0.001) or >7 (p < 0.001). Clinical stage <T2b patients had significantly higher ADC values versus stage T2b (p=0.001) and T2b tumors (p< 0.001). ADC demonstrated stronger correlation with NCCN risk groups (R=-0.510; p< 0.001). All clinical factors except Gleason score had moderate inverse correlation with nADC. Best nADC correlation occurred with NCCN risk groups (R=-0.461; p< 0.001). ADCs measured by DW-MRI are noninvasive prognostic markers of clinical parameters and risk for prostate cancer in RT candidates.
- Subjects
DIFFUSION magnetic resonance imaging; PROSTATE cancer patients; RADIOTHERAPY; TUMORS; PROSTATECTOMY
- Publication
UHOD: International Journal of Hematology & Oncology / Uluslararasi Hematoloji Onkoloji Dergisi, 2015, Vol 25, Issue 2, p88
- ISSN
1306-133X
- Publication type
Article
- DOI
10.4999/uhod.15813