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- Title
Biomodification of compromised extraction sockets using hyaluronic acid and rhBMP-2: An experimental study in dogs.
- Authors
Kim, Jung‐Ju; Ben Amara, Heithem; Park, Jung‐chul; Kim, Sungtae; Kim, Tae‐Il; Seol, Yang‐Jo; Lee, Yong‐Moo; Ku, Young; Rhyu, In‐Chul; Koo, Ki‐Tae; Kim, Jung-Ju; Park, Jung-Chul; Kim, Tae-Il; Seol, Yang-Jo; Lee, Yong-Moo; Rhyu, In-Chul; Koo, Ki-Tae
- Abstract
<bold>Background: </bold>This experimental study aims to evaluate the effect of hyaluronic acid on healing of infected extraction sockets compared with recombinant human bone morphogenetic protein-2 (rhBMP-2).<bold>Methods: </bold>Both third and fourth mandibular premolars of six beagle dogs were hemisected, and the distal roots were extracted at baseline. Subsequently, combined endodontic-periodontic lesions were induced at the remaining mesial roots. After 4 months, the mesial roots on both sides of the mandible were removed. Four sockets per dog were randomly allocated to four groups: Group 1, Control; Group 2, only absorbable collagen sponge (ACS: carrier); Group 3, 1% hyaluronic acid (HA) gel + ACS; and Group 4, rhBMP-2 + ACS. After 3 months of healing, the dogs were euthanized for microcomputed tomography and histologic analysis.<bold>Results: </bold>After the lesion induction period (4 months), communication between the periodontal lesion and endodontic periapical lesion was observed at all remaining mesial roots. Alveolar bone overgrowth was observed in groups 3 and 4, but bone volume density was not significantly different among all groups. At the crestal portion, mineralization, and osteocalcin expression were higher in groups 3 and 4 than in groups 1 and 2.<bold>Conclusion: </bold>Treatment with HA can promote bone formation and improve the wound healing rate comparable to rhBMP-2 in infected extraction sockets.
- Subjects
DENTAL extraction; TOOTH socket; THERAPEUTIC use of hyaluronic acid; WOUND healing; BONE morphogenetic proteins; RECOMBINANT proteins; BICUSPIDS; DENTAL therapeutics
- Publication
Journal of Periodontology, 2019, Vol 90, Issue 4, p416
- ISSN
0022-3492
- Publication type
journal article
- DOI
10.1002/JPER.18-0348