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Chronically elevated branched chain amino acid levels are pro-arrhythmic.
Published in:
Cardiovascular Research, 2022, v. 118, n. 7, p. 1742, doi. 10.1093/cvr/cvab207
By:
- Portero, Vincent;
- Nicol, Thomas;
- Podliesna, Svitlana;
- Marchal, Gerard A;
- Baartscheer, Antonius;
- Casini, Simona;
- Tadros, Rafik;
- Treur, Jorien L;
- Tanck, Michael W T;
- Cox, I Jane;
- Probert, Fay;
- Hough, Tertius A;
- Falcone, Sara;
- Beekman, Leander;
- Müller-Nurasyid, Martina;
- Kastenmüller, Gabi;
- Gieger, Christian;
- Peters, Annette;
- Kääb, Stefan;
- Sinner, Moritz F
Publication type:
Article
Sodium-glucose co-transporter 2 inhibitor empagliflozin inhibits the cardiac Na+/H+ exchanger 1: persistent inhibition under various experimental conditions.
Published in:
Cardiovascular Research, 2021, v. 117, n. 14, p. 2699, doi. 10.1093/cvr/cvab129
By:
- Zuurbier, Coert J;
- Baartscheer, Antonius;
- Schumacher, Cees A;
- Fiolet, Jan W T;
- Coronel, Ruben
Publication type:
Article
Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts.
Published in:
Cardiovascular Research, 2019, v. 115, n. 10, p. 1533, doi. 10.1093/cvr/cvz004
By:
- Uthman, Laween;
- Nederlof, Rianne;
- Eerbeek, Otto;
- Baartscheer, Antonius;
- Schumacher, Cees;
- Buchholtz, Ninée;
- Hollmann, Markus W;
- Coronel, Ruben;
- Weber, Nina C;
- Zuurbier, Coert J
Publication type:
Article
Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis.
Published in:
Cardiovascular Research, 2018, v. 114, n. 12, p. 1617, doi. 10.1093/cvr/cvy125
By:
- Medzikovic, Lejla;
- Roomen, Cindy van;
- Baartscheer, Antonius;
- Loenen, Pieter B van;
- Vos, Judith de;
- Bakker, Erik N T P;
- Koenis, Duco S;
- Damanafshan, Amin;
- Creemers, Esther E;
- Arkenbout, E Karin
Publication type:
Article
Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats.
Published in:
Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00229
By:
- Pytka, Karolina;
- Lustyk, Klaudia;
- Żmudzka, Elżbieta;
- Kotańska, Magdalena;
- Siwek, Agata;
- Zygmunt, Małgorzata;
- Dziedziczak, Agnieszka;
- Śniecikowska, Joanna;
- Olczyk, Adrian;
- Gałuszka, Adam;
- Śmieja, Jarosław;
- Waszkielewicz, Anna M.;
- Marona, Henryk;
- Filipek, Barbara;
- Sapa, Jacek;
- Mogilski, Szczepan;
- Akar, Fadi G.;
- Heijman, Jordi;
- Baartscheer, Antonius
Publication type:
Article
Arrhythmogenesis in Heart Failure.
Published in:
Journal of Cardiovascular Electrophysiology, 2001, v. 12, n. 4, p. 496, doi. 10.1046/j.1540-8167.2001.00496.x
By:
- Janse, Michiel J.;
- Vermeulen, Jessica T.;
- Opthof, Tobias;
- Coronel, Ruben;
- Wilms-Schopman, Francien J. G.;
- Radamaker, Han M. E.;
- Baartscheer, Antonius;
- Dekker, Lukas R. C.
Publication type:
Article
Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning.
Published in:
2016
By:
- Keul, Petra;
- Borren, Marcel M. G. J.;
- Ghanem, Alexander;
- Müller, Frank Ulrich;
- Baartscheer, Antonius;
- Verkerk, Arie O.;
- Stümpel, Frank;
- Schulte, Jan Sebastian;
- Hamdani, Nazha;
- Linke, Wolfgang A.;
- Loenen, Pieter;
- Matus, Marek;
- Schmitz, Wilhelm;
- Stypmann, Jörg;
- Tiemann, Klaus;
- Ravesloot, Jan‐Hindrik;
- Alewijnse, Astrid E.;
- Hermann, Sven;
- Spijkers, Léon J. A.;
- Hiller, Karl‐Heinz
Publication type:
journal article
Arrhythmogenic pulmonary vein myocardium in heart failure.
Published in:
2011
By:
- Boukens, Bastiaan J;
- Baartscheer, Antonius;
- Higa, Satoshi
Publication type:
Editorial
A Heterozygous Deletion Mutation in the Cardiac Sodium Channel Gene SCN5A with Loss- and Gain-of-Function Characteristics Manifests as Isolated Conduction Disease, without Signs of Brugada or Long QT Syndrome.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067963
By:
- Zumhagen, Sven;
- Veldkamp, Marieke W.;
- Stallmeyer, Birgit;
- Baartscheer, Antonius;
- Eckardt, Lars;
- Paul, Matthias;
- Remme, Carol Ann;
- Bhuiyan, Zahurul A.;
- Bezzina, Connie R.;
- Schulze-Bahr, Eric
Publication type:
Article
Is IGF‐1 a useful inhibitor of Na+/H+‐exchanger activity?
Published in:
2018
By:
- Baartscheer, Antonius;
- Veldkamp, Marieke W.
Publication type:
Editorial
Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells.
Published in:
Frontiers in Physiology, 2023, p. 01, doi. 10.3389/fphys.2023.1179131
By:
- Sha Chen;
- Schumacher, Cees A.;
- Van Amersfoorth, Shirley C. M.;
- Fiolet, Jan W. T.;
- Baartscheer, Antonius;
- Veldkamp, Marieke W.;
- Coronel, Ruben;
- Zuurbier, Coert J.
Publication type:
Article
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
Published in:
2020
By:
- Rivaud, Mathilde R;
- Marchal, Gerard A;
- Wolswinkel, Rianne;
- Jansen, John A;
- van der Made, Ingeborg;
- Beekman, Leander;
- Ruiz-Villalba, Adrián;
- Baartscheer, Antonius;
- Rajamani, Sridharan;
- Belardinelli, Luiz;
- Veen, Toon A B van;
- Basso, Cristina;
- Thiene, Gaetano;
- Creemers, Esther E;
- Bezzina, Connie R;
- Remme, Carol Ann;
- van Veen, Toon A B
Publication type:
journal article
Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients.
Published in:
Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01575
By:
- Uthman, Laween;
- Baartscheer, Antonius;
- Schumacher, Cees A.;
- Fiolet, Jan W. T.;
- Kuschma, Marius C.;
- Hollmann, Markus W.;
- Coronel, Ruben;
- Weber, Nina C.;
- Zuurbier, Coert J.
Publication type:
Article
Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart.
Published in:
Journal of Physiology & Biochemistry, 2016, v. 73, n. 3, p. 323, doi. 10.1007/s13105-017-0555-3
By:
- Nederlof, Rianne;
- Gürel-Gurevin, Ebru;
- Eerbeek, Otto;
- Xie, Chaoqin;
- Deijs, G. Sjoerd;
- Konkel, Moritz;
- Hu, Jun;
- Weber, Nina;
- Schumacher, Cees;
- Baartscheer, Antonius;
- Mik, Egbert;
- Hollmann, Markus;
- Akar, Fadi;
- Zuurbier, Coert
Publication type:
Article
In vivo mouse myocardial 31P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.
Published in:
NMR in Biomedicine, 2015, v. 28, n. 10, p. 1218, doi. 10.1002/nbm.3371
By:
- Bakermans, Adrianus J.;
- Abdurrachim, Desiree;
- Nierop, Bastiaan J.;
- Koeman, Anneke;
- Kroon, Inge;
- Baartscheer, Antonius;
- Schumacher, Cees A.;
- Strijkers, Gustav J.;
- Houten, Sander M.;
- Zuurbier, Coert J.;
- Nicolay, Klaas;
- Prompers, Jeanine J.
Publication type:
Article
Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na+/H+ exchanger, lowering of cytosolic Na+ and vasodilation.
Published in:
Diabetologia, 2018, v. 61, n. 3, p. 722, doi. 10.1007/s00125-017-4509-7
By:
- Uthman, Laween;
- Baartscheer, Antonius;
- Bleijlevens, Boris;
- Schumacher, Cees A.;
- Fiolet, Jan W. T.;
- Koeman, Anneke;
- Jancev, Milena;
- Hollmann, Markus W.;
- Weber, Nina C.;
- Coronel, Ruben;
- Zuurbier, Coert J.
Publication type:
Article
Empagliflozin decreases myocardial cytoplasmic Na through inhibition of the cardiac Na/H exchanger in rats and rabbits.
Published in:
Diabetologia, 2017, v. 60, n. 3, p. 568, doi. 10.1007/s00125-016-4134-x
By:
- Baartscheer, Antonius;
- Schumacher, Cees;
- Wüst, Rob;
- Fiolet, Jan;
- Stienen, Ger;
- Coronel, Ruben;
- Zuurbier, Coert
Publication type:
Article
Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials
Published in:
Cardiovascular Research, 2006, v. 70, n. 3, p. 509, doi. 10.1016/j.cardiores.2006.02.022
By:
- Verkerk, Arie O.;
- van Ginneken, Antoni C.G.;
- Berecki, Géza;
- den Ruijter, Hester M.;
- Schumacher, Cees A.;
- Veldkamp, Marieke W.;
- Baartscheer, Antonius;
- Casini, Simona;
- Opthof, Tobias;
- Hovenier, Robert;
- Fiolet, Jan W.T.;
- Zock, Peter L.;
- Coronel, Ruben
Publication type:
Article
Chronic inhibition of Na+/H+-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure
Published in:
Cardiovascular Research, 2005, v. 65, n. 1, p. 83, doi. 10.1016/j.cardiores.2004.09.024
By:
- Baartscheer, Antonius;
- Schumacher, Cees A.;
- van Borren, Marcel M.G.J.;
- Belterman, Charly N.W.;
- Coronel, Ruben;
- Opthof, Tobias;
- Fiolet, Jan W.T.
Publication type:
Article
Intrinsic heterogeneity in repolarization is increased in isolated failing rabbit cardiomyocytes during simulated ischemia
Published in:
Cardiovascular Research, 2003, v. 59, n. 3, p. 705, doi. 10.1016/S0008-6363(03)00460-7
By:
- de Groot, Joris R.;
- Schumacher, Cees A.;
- Verkerk, Arie O.;
- Baartscheer, Antonius;
- Fiolet, Jan W.T.;
- Coronel, Ruben
Publication type:
Article
SR calcium handling and calcium after-transients in a rabbit model of heart failure
Published in:
Cardiovascular Research, 2003, v. 58, n. 1, p. 99, doi. 10.1016/S0008-6363(02)00854-4
By:
- Baartscheer, Antonius;
- Schumacher, Cees A.;
- Belterman, Charly N.W.;
- Coronel, Ruben;
- Fiolet, Jan W.T.
Publication type:
Article
Reduced swelling-activated Cl− current densities in hypertrophied ventricular myocytes of rabbits with heart failure
Published in:
Cardiovascular Research, 2002, v. 53, n. 4, p. 869, doi. 10.1016/S0008-6363(01)00507-7
By:
- van Borren, Marcel M.G.J.;
- Verkerk, Arie O.;
- Vanharanta, Sakari K.;
- Baartscheer, Antonius;
- Coronel, Ruben;
- Ravesloot, Jan H.
Publication type:
Article
Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 7, p. 2589, doi. 10.3390/ijms21072589
By:
- Knottnerus, Suzan J. G.;
- Mengarelli, Isabella;
- Wüst, Rob C. I.;
- Baartscheer, Antonius;
- Bleeker, Jeannette C.;
- Coronel, Ruben;
- Ferdinandusse, Sacha;
- Guan, Kaomei;
- IJlst, Lodewijk;
- Li, Wener;
- Luo, Xiaojing;
- Portero, Vincent M.;
- Ulbricht, Ying;
- Visser, Gepke;
- Wanders, Ronald J. A.;
- Wijburg, Frits A.;
- Verkerk, Arie O.;
- Houtkooper, Riekelt H.;
- Bezzina, Connie R.
Publication type:
Article
Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel.
Published in:
Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06530-5
By:
- Veldkamp, Marieke W.;
- Geuzebroek, Guillaume S. C.;
- Baartscheer, Antonius;
- Verkerk, Arie O.;
- Schumacher, Cees A.;
- Suarez, Gedeon G.;
- Berger, Wouter R.;
- Casini, Simona;
- van Amersfoorth, Shirley C. M.;
- Scholman, Koen T.;
- Driessen, Antoine H. G.;
- Belterman, Charly N. W.;
- van Ginneken, Antoni C. G.;
- de Groot, Joris R.;
- de Bakker, Jacques M. T.;
- Remme, Carol Ann;
- Boukens, Bas J.;
- Coronel, Ruben
Publication type:
Article

Found: 24

Chronically elevated branched chain amino acid levels are pro-arrhythmic.

Sodium-glucose co-transporter 2 inhibitor empagliflozin inhibits the cardiac Na+/H+ exchanger 1: persistent inhibition under various experimental conditions.

Delayed ischaemic contracture onset by empagliflozin associates with NHE1 inhibition and is dependent on insulin in isolated mouse hearts.

Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis.

Chemically Homogenous Compounds with Antagonistic Properties at All α<sub>1</sub>-Adrenoceptor Subtypes but not β<sub>1</sub>-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats.

Arrhythmogenesis in Heart Failure.

Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning.

Arrhythmogenic pulmonary vein myocardium in heart failure.

A Heterozygous Deletion Mutation in the Cardiac Sodium Channel Gene SCN5A with Loss- and Gain-of-Function Characteristics Manifests as Isolated Conduction Disease, without Signs of Brugada or Long QT Syndrome.

Is IGF‐1 a useful inhibitor of Na<sup>+</sup>/H<sup>+</sup>‐exchanger activity?

Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells.

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.

Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart Failure in Diabetic Patients.

Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart.

In vivo mouse myocardial <sup>31</sup>P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations.

Class effects of SGLT2 inhibitors in mouse cardiomyocytes and hearts: inhibition of Na<sup>+</sup>/H<sup>+</sup> exchanger, lowering of cytosolic Na<sup>+</sup> and vasodilation.

Empagliflozin decreases myocardial cytoplasmic Na through inhibition of the cardiac Na/H exchanger in rats and rabbits.

Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials

Chronic inhibition of Na<sup>+</sup>/H<sup>+</sup>-exchanger attenuates cardiac hypertrophy and prevents cellular remodeling in heart failure

Intrinsic heterogeneity in repolarization is increased in isolated failing rabbit cardiomyocytes during simulated ischemia

SR calcium handling and calcium after-transients in a rabbit model of heart failure

Reduced swelling-activated Cl<sup>−</sup> current densities in hypertrophied ventricular myocytes of rabbits with heart failure

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates.

Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K<sup>+</sup> channel.