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- Title
Blocking of angiotensin II is more than blocking of transforming growth factor-β.
- Authors
Daniel, Christoph
- Abstract
Fibrosis is a common feature of chronic kidney diseases that is mediated by matrix-producing myofibroblasts. One potential origin of myofibroblasts is epithelial–mesenchymal transition (EMT) of tubuloepithelial cells. Transforming growth factor-β (TGF-β) is a key factor inducing EMT. Carvajal et al. demonstrate that angiotensin II induces EMT by classical stimulation of TGF-β and also by a TGF-β-independent pathway, both signaling via Smad molecules. Therefore, blockade of angiotensin II is more than lowering of blood pressure and inhibition of TGF-β stimulation.Kidney International (2008) 74, 551–553. doi:10.1038/ki.2008.290
- Subjects
FIBROSIS; KIDNEY diseases; ANGIOTENSIN II; TRANSFORMING growth factors; BLOOD pressure
- Publication
Kidney International, 2008, Vol 74, Issue 5, p551
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2008.290